Rabbit IGF BP5 Polyclonal Antibody | anti-IGF BP5 antibody

IGF BP5 antibody

Cat. Num. AAA535907

• Gene Names: Igfbp5; IGF-BP5
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot, ELISA
• Synonyms: IGF BP5; Polyclonal Antibody; IGF BP5 antibody; Polyclonal IGF BP5; Anti-IGF BP5; IGF BP-5; IGF BP 5; Insulin-like Growth Factor-Binding5; anti-IGF BP5 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: Human IGF BP5
• Form/Format: Sterile filtered and lyophilized from PBS. pH 7.2. Reconstitute with sterile water to 0.1 - 1.0mg/ml
• Concentration: 50ug, lyophilized (varies by lot)
• Sequence Length: 271

• Applicable Applications for anti-IGF BP5 antibody: Suitable for use in Immunostaining, Western Blot (WB), and Sandwich ELISA (EIA)
• Application Notes: Optimal conditions to be determined by end user.
• Biological Significance: IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP5 is a 28.6 kDa cysteine-rich secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP-5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells.
• Immunogen: E. Coli derived Reco, binant Human IGF-BP5
• Preparation and Storage: Ships ambient or refrigerated. Upon receipt store at 4°C short term or -20°C long term.

Related Product Information for anti-IGF BP5 antibody

Affinity purified Rabbit polyclonal IGF BP5 antibody

Product Categories/Family for anti-IGF BP5 antibody

Cytokines & Growth Factors; Purified Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 6981088
• NCBI GeneID: 25285
• NCBI Accession #: NP_036949.1
• NCBI GenBank Nucleotide #: NM_012817.1
• UniProt Accession #: P24594
• Molecular Weight: 28.6 kDa (predicted detection band MW)
• NCBI Official Full Name: insulin-like growth factor-binding protein 5
• NCBI Official Synonym Full Names: insulin-like growth factor binding protein 5
• NCBI Official Symbol: Igfbp5
• NCBI Official Synonym Symbols: IGF-BP5
• NCBI Protein Information: insulin-like growth factor-binding protein 5
• UniProt Protein Name: Insulin-like growth factor-binding protein 5
• UniProt Gene Name: Igfbp5
• UniProt Synonym Gene Names: Igfbp-5; IBP-5; IGF-binding protein 5; IGFBP-5
• UniProt Entry Name: IBP5_RAT

NCBI Description

may be involved in ovarian folliculogenesis and may play a modulatory role in type I fiber-dominated muscles [RGD, Feb 2006]

Uniprot Description

IGFBP5: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Protein type: Secreted; Cell cycle regulation; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: insulin-like growth factor binding; insulin-like growth factor I binding; fibronectin binding; insulin-like growth factor II binding

Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; mammary gland involution; regulation of insulin-like growth factor receptor signaling pathway; hair follicle morphogenesis; negative regulation of smooth muscle cell proliferation; negative regulation of insulin-like growth factor receptor signaling pathway; glucose metabolic process; negative regulation of smooth muscle cell migration; glucose homeostasis; osteoblast differentiation; positive regulation of protein kinase B signaling cascade; regulation of growth; negative regulation of translation; striated muscle cell differentiation; negative regulation of osteoblast differentiation; skeletal muscle growth; regulation of cell growth; negative regulation of cell migration