Rabbit IGF BP3 Polyclonal Antibody | anti-IGF BP3 antibody

IGF BP3 antibody

Cat. Num. AAA535722

• Gene Names: Igfbp3; IGF-BP3
• Reactivity: human IGF BP3
• Applications: ELISA, Western Blot
• Synonyms: IGF BP3; Polyclonal Antibody; IGF BP3 antibody; Polyclonal IGF BP3; Anti-IGF BP3; IGF BP-3; Insulin-like Growth Factor-Binding 3; IGF BP 3; Growth-hormone-dependant binding; anti-IGF BP3 antibody

• Host: Rabbit
• Reactivity: human IGF BP3
• Clonality: Polyclonal
• Specificity: human IGF BP3
• Form/Format: Lyophilized from PBS, pH 7.2.
• Sequence Length: 292

• Applicable Applications for anti-IGF BP3 antibody: ELISA (EIA), Inhibition, Western Blot (WB)
• Biological Significance: IGF-BP3 is a 30 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in a-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly.
• Immunogen: IGF BP3 antibody was raised in rabbit using highly pure recombinant human IGF-BP3 as the immunogen.
• Preparation and Storage: Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-IGF BP3 antibody

Affinity purified Rabbit polyclonal IGF BP3 antibody

Product Categories/Family for anti-IGF BP3 antibody

Cytokines & Growth Factors; Purified Polyclonal Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 298231182
• NCBI GeneID: 24484
• NCBI Accession #: NP_036720.2
• NCBI GenBank Nucleotide #: NM_012588.2
• UniProt Accession #: P15473
• Molecular Weight: 28.8 kDa (predicted detection band MW)
• NCBI Official Full Name: insulin-like growth factor-binding protein 3
• NCBI Official Synonym Full Names: insulin-like growth factor binding protein 3
• NCBI Official Symbol: Igfbp3
• NCBI Official Synonym Symbols: IGF-BP3
• NCBI Protein Information: insulin-like growth factor-binding protein 3
• UniProt Protein Name: Insulin-like growth factor-binding protein 3
• UniProt Gene Name: Igfbp3
• UniProt Synonym Gene Names: Igfbp-3; IBP-3; IGF-binding protein 3; IGFBP-3
• UniProt Entry Name: IBP3_RAT

NCBI Description

an insulin growth factor (Igf) binding protein; involved in modulating IGF-I action [RGD, Feb 2006]

Uniprot Description

IGFBP3: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

Protein type: Secreted; Cell development/differentiation; Secreted, signal peptide

Cellular Component: extracellular space; nucleus

Molecular Function: insulin-like growth factor binding; protein binding; insulin-like growth factor I binding; fibronectin binding; insulin-like growth factor II binding; protein tyrosine phosphatase activator activity

Biological Process: positive regulation of catalytic activity; positive regulation of insulin-like growth factor receptor signaling pathway; regulation of insulin-like growth factor receptor signaling pathway; positive regulation of apoptosis; negative regulation of smooth muscle cell proliferation; negative regulation of smooth muscle cell migration; protein amino acid phosphorylation; positive regulation of myoblast differentiation; osteoblast differentiation; negative regulation of cell proliferation; negative regulation of protein amino acid phosphorylation; positive regulation of MAPKKK cascade; regulation of growth; regulation of cell growth