Rabbit anti-Human IFNA4 Polyclonal Antibody | anti-IFNA4 antibody

IFNA4 (Interferon alpha-4, IFN-alpha-4, Interferon alpha-4B, Interferon alpha-76, Interferon alpha-M1, MGC142200)

Cat. Num. AAA6003949

• Gene Names: IFNA4; INFA4; IFN-alpha4a
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: IFNA4; Polyclonal Antibody; IFNA4 (Interferon alpha-4; IFN-alpha-4; Interferon alpha-4B; Interferon alpha-76; Interferon alpha-M1; MGC142200); Anti -IFNA4 (Interferon alpha-4; anti-IFNA4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human IFNA4.
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2.
• Sequence: MALSFSLLMAVLVLSYKSICSLGCDLPQTHSLGNRRALILLAQMGRISHFSCLKDRHDFGFPEEEFDGHQFQKAQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNDLEACVIQEVGVEETPLMNVDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTNLQKRLRRKD

• Applicable Applications for anti-IFNA4 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Immunogen: Full length human IFNA4, aa1-189 (NP_066546.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of IFNA4 expression in transfected 293T cell line by IFNA4 polyclonal antibody. Lane 1: IFNA4 transfected lysate (21.8kD). Lane 2: Non-transfected lysate)

Related Product Information for anti-IFNA4 antibody

Most mammalian species have multiple IFN-a subtypes. Although the reasons for these multiple subtypes are not fully known, there are clear cell type and temporal differences in their expression. A recent study established a nomenclature for the murine IFN-a subtypes (van Pesch et al. 2004) and determined relative activities of the subtypes with protein quantification by phosphorimaging of metabolically-labeled protein. In this study, Mu IFN-a4 was deemed to have average antiviral activity when compared with the potency of the other subtypes. Mu IFN-a4 was initially cloned by Zwarthoff et al. [(1985) Nuc. Acids Res. 13(3) 791], and has been extensively studied. It is apparently expressed early in viral infection in a protein synthesis independent manner, and its expression is induced by phosphorylation of IRF-3. It may be that Mu IFN-a4, like IFN-b, has a priming function on cells, enabling the expression of other Mu IFN-a subtypes [Reviewed by Mesplède et al. (2003) Autoimmunity 36(8):447 and Asselin-Paturel & Trinchieri (2005) J. Exp. Med. 202(4):461]. Thus, this interferon is among the first observed after viral infection. Intriguingly, while this interferon is expressed in a large variety of cell types, one report suggests that the expression level in dendritic cells is low to non-existent [Barchet et al. (2002) J. Exp. Med. 195(4):507]

Product Categories/Family for anti-IFNA4 antibody

Antibodies; Abs to Interferon

NCBI and Uniprot Product Information

• NCBI GI #: 10835103
• NCBI GeneID: 3441
• NCBI Accession #: NP_066546.1
• NCBI GenBank Nucleotide #: NM_021068.2
• UniProt Accession #: P05014; P13358; Q14CS4; Q5VV15
• Molecular Weight: 21,808 Da
• NCBI Official Full Name: interferon alpha-4
• NCBI Official Synonym Full Names: interferon, alpha 4
• NCBI Official Symbol: IFNA4
• NCBI Official Synonym Symbols: INFA4; IFN-alpha4a
• NCBI Protein Information: interferon alpha-4; IFN-alpha-4; interferon alpha-4B; interferon alpha-76; interferon alpha-M1
• UniProt Protein Name: Interferon alpha-4
• UniProt Gene Name: IFNA4
• UniProt Synonym Gene Names: IFN-alpha-4
• UniProt Entry Name: IFNA4_HUMAN

Uniprot Description

IFNA4: Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. Belongs to the alpha/beta interferon family.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 9p22

Cellular Component: extracellular space; extracellular region

Molecular Function: interferon-alpha/beta receptor binding; cytokine activity

Biological Process: B cell proliferation; adaptive immune response; cytokine and chemokine mediated signaling pathway; response to virus; regulation of MHC class I biosynthetic process; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; B cell differentiation; natural killer cell activation during immune response; innate immune response; blood coagulation; defense response to virus; positive regulation of peptidyl-serine phosphorylation of STAT protein