Rabbit anti-Human IFITM2 Polyclonal Antibody | anti-IFITM2 antibody

Anti-IFITM2 Antibody, Rabbit Polyclonal

Cat. Num. AAA8103535

• Gene Names: IFITM2; 1-8D; DSPA2c
• Reactivity: Human
• Applications: Western Blot
• Purity: Protein A & Antigen Affinity
• Synonyms: IFITM2; Polyclonal Antibody; Anti-IFITM2 Antibody; Rabbit Polyclonal; IFITM2 Antibody; Rabbit PAb; Antigen Affinity Purified; interferon induced transmembrane protein 2; Anti-1-8D Antibody; Anti-DSPA2c Antibody; anti-IFITM2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human IFITM2
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-IFITM2 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthetic peptide corresponding to the center region of the Human IFITM2
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human IFITM2, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Western Blot (WB)

(Anti-IFITM2 rabbit polyclonal antibody at 1:500 dilution Lane A: NCI-H460 Whole Cell Lysate Lane B: HepG2 Whole Cell Lysate Lysates/proteins at 30 ug per lane. Secondary Goat Anti-Rabbit IgG (H+L)/HRP at 1/10000 dilution. Developed using the ECL technique. Performed under reducing conditions. Predicted band size:15 kDa Observed band size:17 kDa)

Related Product Information for anti-IFITM2 antibody

IFITM2 (Interferon Induced Transmembrane Protein 2) is a Protein Coding gene. The encoded protein IFITM2 belongs to the CD225/Dispanin family. IFITM2 knockdown decreased GC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition in vitro. And IFITM2 expression was in part induced by insulin-like growth factor (IGF) 1 via IGF1 receptor/signal transducer and activator of transcription 3 signaling. Furthermore, IFITM2 regulated interleukin-6 expression and secretion, which in turn increased IFITM2 expression. Silencing of IFITM2 expression suppressed tumor growth and lung metastasis in vivo. That IFITM2 is a novel prognostic biomarker and regulator of GC progression. IFITM2 is widely expressed in the appendix, spleen, and other tissues. Diseases associated with IFITM2 include Cycloplegia and Influenza.

NCBI and Uniprot Product Information

• NCBI GI #: 151101191
• NCBI GeneID: 10581
• NCBI Accession #: NP_006426.2
• NCBI GenBank Nucleotide #: NM_006435.2
• UniProt Accession #: Q01629; Q6FH82; Q96DA8
• Molecular Weight: 14,632 Da
• NCBI Official Full Name: interferon-induced transmembrane protein 2
• NCBI Official Synonym Full Names: interferon induced transmembrane protein 2
• NCBI Official Symbol: IFITM2
• NCBI Official Synonym Symbols: 1-8D; DSPA2c
• NCBI Protein Information: interferon-induced transmembrane protein 2
• UniProt Protein Name: Interferon-induced transmembrane protein 2
• Protein Family: Interferon-induced transmembrane protein
• UniProt Gene Name: IFITM2
• UniProt Synonym Gene Names: DSPA2c
• UniProt Entry Name: IFM2_HUMAN

Uniprot Description

IFITM2: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein- mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. Belongs to the CD225/Dispanin family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: integral to membrane; plasma membrane

Biological Process: cytokine and chemokine mediated signaling pathway; defense response to virus; immune response; negative regulation of viral genome replication; negative regulation of virion penetration into host cell; response to virus