Rabbit anti-Human IFITM1 Polyclonal Antibody | anti-IFITM1 antibody

IFITM1, ID (IFITM1, CD225, IFI17, Interferon-induced transmembrane protein 1, Dispanin subfamily A member 2a, Interferon-induced protein 17, Interferon-inducible protein 9-27, Leu-13 antigen, CD225) (PE)

Cat. Num. AAA6309287

• Gene Names: IFITM1; 9-27; CD225; IFI17; LEU13; DSPA2a
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: IFITM1; Polyclonal Antibody; ID (IFITM1; CD225; IFI17; Interferon-induced transmembrane protein 1; Dispanin subfamily A member 2a; Interferon-induced protein 17; Interferon-inducible protein 9-27; Leu-13 antigen; CD225) (PE); anti-IFITM1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

• Applicable Applications for anti-IFITM1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: IFITM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the Central region of human IFITM1.
• Conjugate: PE
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(IFITM1 Antibody (Center) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the IFITM1 antibody detected the IFITM1 protein (arrow).)

Related Product Information for anti-IFITM1 antibody

IFN-induced antiviral protein that mediate cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus, and dengue virus by inhibiting the early step(s) of replication. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activition or by arresting cell growth in G1 phase in a p53-dependent manner. Implicated in the control of cell growth. Component of a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals.

Product Categories/Family for anti-IFITM1 antibody

Antibodies; Transmembrane Proteins

References

Ma, Y., et al. Oncol. Rep. 23(6):1569-1576(2010). Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010). Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010): Pan, Z., et al. Neoplasma 57(2):123-128(2010). Brass, A.L., et al. Cell 139(7):1243-1254(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 150010589
• NCBI GeneID: 8519
• NCBI Accession #: NP_003632.3
• NCBI GenBank Nucleotide #: NM_003641.3
• UniProt Accession #: P13164; Q15322; Q53XZ0; AAB25699
• Molecular Weight: 13,964 Da
• NCBI Official Full Name: interferon-induced transmembrane protein 1
• NCBI Official Synonym Full Names: interferon induced transmembrane protein 1
• NCBI Official Symbol: IFITM1
• NCBI Official Synonym Symbols: 9-27; CD225; IFI17; LEU13; DSPA2a
• NCBI Protein Information: interferon-induced transmembrane protein 1; leu-13 antigen; interferon-induced protein 17; dispanin subfamily A member 2a; interferon-inducible protein 9-27
• UniProt Protein Name: Interferon-induced transmembrane protein 1
• Protein Family: Interferon-induced transmembrane protein
• UniProt Gene Name: IFITM1
• UniProt Synonym Gene Names: CD225; IFI17; DSPA2a
• UniProt Entry Name: IFM1_HUMAN

Uniprot Description

IFITM1: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV). Can inhibit: influenza virus hemagglutinin protein- mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. Belongs to the CD225/Dispanin family.

Protein type: Cell cycle regulation; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: protein binding; receptor signaling protein activity

Biological Process: positive regulation of osteoblast differentiation; negative regulation of cell proliferation; regulation of immune response; ossification; cell surface receptor linked signal transduction; negative regulation of viral genome replication; negative regulation of virion penetration into host cell; cytokine and chemokine mediated signaling pathway; response to virus; defense response to virus; negative regulation of cell migration