Western Blot (WB)
(Western blot analysis of extracts from HeLa cells and HepG2 cells, using IFI16 antibody.)
Rabbit anti-Human IFI16 Polyclonal Antibody | anti-IFI16 antibody
IFI16 Antibody
Western Blot (WB)
(Western blot analysis of extracts from HeLa cells and HepG2 cells, using IFI16 antibody.)
Western Blot (WB)
(Western blot analysis of extracts from HeLa cells and HepG2 cells, using IFI16 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
Uniprot Description
IFI16: a nuclear protein that may function as a transcriptional repressor. Strongly induced by gamma interferon and, to a lesser extent, by alpha interferon. Binds double-stranded DNA and cell cycle regulatory factors including p53 and Rb. Loss of IFI16 activates p53 checkpoint through NBS1-DNAPK pathway. Inhibits cell growth in the Ras/Raf signaling pathway. May be involved in the senescence of prostate epithelial cells. Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prostate, ovary and breast. Four alternatively spliced isoforms have been described. Isoforms-1, -2 and -3 can homo- and hetero-dimerize.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 1q22
Cellular Component: nucleoplasm; membrane; cytoplasm; nucleolus; nuclear speck; nucleus; cytosol
Molecular Function: identical protein binding; protein binding; double-stranded DNA binding; transcription factor binding
Biological Process: positive regulation of cytokine production; transcription, DNA-dependent; monocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic; negative regulation of DNA binding; positive regulation of interleukin-1 beta production; cell proliferation; cellular response to glucose starvation; negative regulation of viral genome replication; negative regulation of innate immune response; positive regulation of interferon type I production; innate immune response; autophagy; hemopoiesis; regulation of autophagy; myeloid cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; inflammatory response; activation of innate immune response; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; defense response to virus
Research Articles on IFI16
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Product Notes
The IFI16 ifi16 (Catalog #AAA9413167) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IFI16 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's IFI16 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting: 1:500~1:3000. Researchers should empirically determine the suitability of the IFI16 ifi16 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IFI16, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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