Rabbit anti-Human ICA1 Polyclonal Antibody | anti-ICA1 antibody

ICA1, NT (ICA1, Islet cell autoantigen 1, 69kD islet cell autoantigen, Islet cell autoantigen p69)

Cat. Num. AAA6003589

• Gene Names: ICA1; ICA69; ICAp69
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: ICA1; Polyclonal Antibody; NT (ICA1; Islet cell autoantigen 1; 69kD islet cell autoantigen; Islet cell autoantigen p69); Anti -ICA1; anti-ICA1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-ICA1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: ICA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-111 amino acids from the N-terminal region of human ICA1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(ICA1 Antibody (N-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the ICA1 antibody detected the ICA1 protein (arrow).)

Related Product Information for anti-ICA1 antibody

This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Product Categories/Family for anti-ICA1 antibody

Antibodies; Abs to Disease Markers

NCBI and Uniprot Product Information

• NCBI GI #: 209862841
• NCBI GeneID: 3382
• NCBI Accession #: NP_001129492.1
• NCBI GenBank Nucleotide #: NM_001136020.2
• UniProt Accession #: Q05084; P78506; Q13824; A8K7U1; B3FTQ2
• Molecular Weight: 54,645 Da
• NCBI Official Full Name: islet cell autoantigen 1 isoform a
• NCBI Official Synonym Full Names: islet cell autoantigen 1, 69kDa
• NCBI Official Symbol: ICA1
• NCBI Official Synonym Symbols: ICA69; ICAp69
• NCBI Protein Information: islet cell autoantigen 1; p69; islet cell autoantigen p69; 69 kDa islet cell autoantigen; islet cell autoantigen 1 isoform; diabetes mellitus type I autoantigen
• UniProt Protein Name: Islet cell autoantigen 1
• Protein Family: Islet cell autoantigen
• UniProt Gene Name: ICA1
• UniProt Synonym Gene Names: ICA69; ICAp69; p69
• UniProt Entry Name: ICA69_HUMAN

NCBI Description

This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Uniprot Description

ICA1: May play a role in neurotransmitter secretion.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 7p22

Cellular Component: Golgi membrane; synaptic vesicle membrane; secretory granule membrane; cytoplasm; cytosol; cell junction

Molecular Function: protein domain specific binding

Biological Process: neurotransmitter transport