Western Blot (WB)
(Anti-HYAL1 antibody, MBS177085, Western blottingLane 1: NRK Cell LysateLane 2: Mouse Liver Tissue LysateLane 3: Mouse Kidney Tissue LysateLane 4: SP2/0 Cell Lysate )
Rabbit anti-Mouse HYAL1 Polyclonal Antibody | anti-HYAL1 antibody
Anti-HYAL1 antibody
Western Blot (WB)
(Anti-HYAL1 antibody, MBS177085, Western blottingLane 1: NRK Cell LysateLane 2: Mouse Liver Tissue LysateLane 3: Mouse Kidney Tissue LysateLane 4: SP2/0 Cell Lysate )
Western Blot (WB)
(Anti-HYAL1 antibody, MBS177085, Western blottingLane 1: NRK Cell LysateLane 2: Mouse Liver Tissue LysateLane 3: Mouse Kidney Tissue LysateLane 4: SP2/0 Cell Lysate )
Background: Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is though to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.
NCBI and Uniprot Product Information
Uniprot Description
HYAL1: May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Defects in HYAL1 are the cause of mucopolysaccharidosis type 9 (MPS9); also called hyaluronidase deficiency. MPS9 is a lysosomal storage disease characterized by high hyaluronan (HA) concentration in the serum. The clinical features are periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. Belongs to the glycosyl hydrolase 56 family. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Hydrolase; Secreted, signal peptide; EC 3.2.1.35; Glycan Metabolism - glycosaminoglycan degradation; Secreted
Cellular Component: extracellular space; lysosome; cytoplasm; extracellular region; cytoplasmic vesicle
Molecular Function: viral receptor activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds; hyaluronan synthase activity; transcription factor binding; catalytic activity; hyalurononglucosaminidase activity
Biological Process: positive regulation of cell adhesion; metabolic process; response to virus; positive regulation of cell growth; hyaluronan catabolic process; response to antibiotic; response to reactive oxygen species; positive regulation of angiogenesis; hyaluronan biosynthetic process; carbohydrate metabolic process; negative regulation of cell growth; inflammatory response; hyaluronan metabolic process; positive regulation of growth; positive regulation of epithelial cell proliferation
Research Articles on HYAL1
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Product Notes
The HYAL1 hyal1 (Catalog #AAA177085) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-HYAL1 antibody reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's HYAL1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the HYAL1 hyal1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HYAL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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