Rabbit anti-Human HVCN1 Polyclonal Antibody | anti-HVCN1 antibody

HVCN1, CT (Voltage-gated Hydrogen Channel 1, Hydrogen Voltage-gated Channel 1, HV1, Voltage Sensor Domain-only Protein, VSOP, UNQ578/PRO1140)

Cat. Num. AAA649674

• Gene Names: HVCN1; HV1; VSOP
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: HVCN1; Polyclonal Antibody; CT (Voltage-gated Hydrogen Channel 1; Hydrogen Voltage-gated Channel 1; HV1; Voltage Sensor Domain-only Protein; VSOP; UNQ578/PRO1140); Anti -HVCN1; anti-HVCN1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human HVCN1. Species sequence homology: mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-HVCN1 antibody: ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Western Blot and Immunohistochemistry.; Dilution: Western Blot: 0.5-1ug/ml; Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
• Immunogen: Synthetic peptide corresponding to 17aa from human HVCN1 at C-terminus.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-HVCN1 antibody

Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.

Product Categories/Family for anti-HVCN1 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 34783432
• NCBI GeneID: 84329
• UniProt Accession #: Q96D96; Q6UW11; Q96IS5; A8MQ37; B4DEB3; F8WCH5
• Molecular Weight: 31,683 Da
• NCBI Official Full Name: HVCN1 protein
• NCBI Official Synonym Full Names: hydrogen voltage-gated channel 1
• NCBI Official Symbol: HVCN1
• NCBI Official Synonym Symbols: HV1; VSOP
• NCBI Protein Information: voltage-gated hydrogen channel 1; voltage sensor domain-only protein
• UniProt Protein Name: Voltage-gated hydrogen channel 1
• Protein Family: Voltage-gated hydrogen channel
• UniProt Gene Name: HVCN1
• UniProt Synonym Gene Names: VSOP; HV1
• UniProt Entry Name: HVCN1_HUMAN

NCBI Description

This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Uniprot Description

Function: Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. Ref.6

Enzyme regulation: Sensitive to zinc ions and is inhibited by them. Ref.6

Subunit structure: Homodimer. Ref.7

Subcellular location: Membrane; Multi-pass membrane protein. Note: Associates mainly with intracellular compartment membranes. Ref.6 Ref.7

Tissue specificity: Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen. Ref.6

Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain.The C-terminal coiled coil region mediates homodimerization and is essential for localization.

Sequence similarities: Belongs to the hydrogen channel family.

Sequence caution: The sequence AAQ89413.1 differs from that shown. Reason: Frameshift at positions 164 and 175.