Rabbit anti-Human HTR3A Polyclonal Antibody | anti-HTR3A antibody

HTR3A, NT (HTR3A, 5HT3R, HTR3, 5-hydroxytryptamine receptor 3A, 5-hydroxytryptamine receptor 3, Serotonin receptor 3A, Serotonin-gated ion channel receptor) (MaxLight 490)

Cat. Num. AAA6308843

• Gene Names: HTR3A; HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: HTR3A; Polyclonal Antibody; NT (HTR3A; 5HT3R; HTR3; 5-hydroxytryptamine receptor 3A; 5-hydroxytryptamine receptor 3; Serotonin receptor 3A; Serotonin-gated ion channel receptor) (MaxLight 490); Serotonin-gated ion channel receptor; anti-HTR3A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

• Applicable Applications for anti-HTR3A antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: HTR3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the N-terminal region of human HTR3A.
• Conjugate: MaxLight490
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-HTR3A antibody

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.

Product Categories/Family for anti-HTR3A antibody

Antibodies; Receptors

References

Gatt, J.M., et al. Biol. Psychiatry 68(9):818-824(2010). Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Gatt, J.M., et al. Depress Anxiety 27(8):752-759(2010). Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010). Hammer, C., et al. Pharmacogenomics 11(7):943-950(2010).

NCBI and Uniprot Product Information

• NCBI GI #: 253735697
• NCBI GeneID: 3359
• NCBI Accession #: NP_998786.2; NP_000860.2; NP_001155244.1
• NCBI GenBank Nucleotide #: NM_213621.3
• UniProt Accession #: P46098; O60854; Q7KZM7; Q99918; Q9BSZ9; B4DSY6; G5E986
• Molecular Weight: 59,002 Da
• NCBI Official Full Name: 5-hydroxytryptamine receptor 3A isoform a
• NCBI Official Synonym Full Names: 5-hydroxytryptamine receptor 3A
• NCBI Official Symbol: HTR3A
• NCBI Official Synonym Symbols: HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R
• NCBI Protein Information: 5-hydroxytryptamine receptor 3A
• UniProt Protein Name: 5-hydroxytryptamine receptor 3A
• Protein Family: 5-hydroxytryptamine receptor
• UniProt Gene Name: HTR3A
• UniProt Synonym Gene Names: 5HT3R; HTR3; 5-HT3-A; 5-HT3A; 5-HT-3; 5-HT3R
• UniProt Entry Name: 5HT3A_HUMAN

NCBI Description

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, cation; Membrane protein, multi-pass; Transporter, ion channel; Channel, ligand-gated; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: postsynaptic membrane; cell soma; axon; integral to plasma membrane; cytoplasm; plasma membrane; cell junction

Molecular Function: serotonin-activated cation-selective channel activity; voltage-gated potassium channel activity; serotonin binding; serotonin receptor activity; receptor activity

Biological Process: synaptic transmission; response to ethanol; transport; digestion; response to cocaine; transmembrane transport; serotonin receptor signaling pathway