Western Blot (WB)
(HSP90AB1 rabbit polyclonal antibody. Western Blot analysis of expression in HeLa.)
Rabbit anti-Human HSP90AB1 Polyclonal Antibody | anti-HSP90AB1 antibody
HSP90AB1 (HSP90B, HSPC2, HSPCB, Heat Shock Protein HSP 90-beta, Heat Shock 84kD, FLJ26984) (AP)
Western Blot (WB)
(HSP90AB1 rabbit polyclonal antibody. Western Blot analysis of expression in HeLa.)
Western Blot (WB)
(HSP90AB1 rabbit polyclonal antibody. Western Blot analysis of expression in HeLa.)
Western Blot (WB)
(Western Blot analysis of HSP90AB1 expression in transfected 293T cell line by HSP90AB1 polyclonal antibody. Lane 1: HSP90AB1 transfected lysate (83.3kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of HSP90AB1 expression in transfected 293T cell line by HSP90AB1 polyclonal antibody. Lane 1: HSP90AB1 transfected lysate (83.3kD). Lane 2: Non-transfected lysate.)
Testing Data
(Proximity Ligation Analysis (PLA) of protein-protein interactions between HSP90AB1 and FLNA. HeLa cells were stained with HSP90AB1 rabbit purified polyclonal 1:1200 and FLNA mouse monoclonal antibody 1:50. Signals were detected 30 Detection Kit (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.)
Testing Data
(Proximity Ligation Analysis (PLA) of protein-protein interactions between HSP90AB1 and FLNA. HeLa cells were stained with HSP90AB1 rabbit purified polyclonal 1:1200 and FLNA mouse monoclonal antibody 1:50. Signals were detected 30 Detection Kit (red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex.)
NCBI and Uniprot Product Information
Uniprot Description
HSP90B: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Homodimer. Interacts with p53/TP53. Forms a complex with CDK6 and Hsp90/HSP90AB1. Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer. Interacts with CHORDC1 and DNAJC7. Interacts with FKBP4. Belongs to the heat shock protein 90 family.
Protein type: Chaperone; Heat shock protein
Chromosomal Location of Human Ortholog: 6p12
Cellular Component: nucleoplasm; signalosome; cell surface; membrane; mitochondrion; brush border membrane; basolateral plasma membrane; cytoplasm; apical plasma membrane; melanosome; inclusion body; cytosol
Molecular Function: protein binding; GTP binding; TPR domain binding; nitric-oxide synthase regulator activity; unfolded protein binding; double-stranded RNA binding; dATP binding; sulfonylurea receptor binding; kinase binding; protein kinase binding; ATP binding
Biological Process: axon guidance; positive regulation of nitric oxide biosynthetic process; protein folding; positive regulation of cell size; positive regulation of protein import into nucleus, translocation; positive regulation of protein binding; innate immune response; negative regulation of neuron apoptosis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; response to unfolded protein; response to salt stress; placenta development
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Product Notes
The HSP90AB1 hsp90ab1 (Catalog #AAA6381793) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HSP90AB1 (HSP90B, HSPC2, HSPCB, Heat Shock Protein HSP 90-beta, Heat Shock 84kD, FLJ26984) (AP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HSP90AB1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the HSP90AB1 hsp90ab1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HSP90AB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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