Western Blot (WB)
(Anti- HSD11B2 antibody, Western blotting)
HSD11B2 Polyclonal Antibody | anti-HSD11B2 antibody
Anti-HSD11B2 Antibody
Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml
Western Blot (WB)
(Anti- HSD11B2 antibody, Western blotting)
Western Blot (WB)
(Anti- HSD11B2 antibody, Western blotting)
Immunohistochemistry (IHC)
(Anti- HSD11B2 antibody, IHC(P)IHC(P): Mouse Pancreas Tissue)
Immunohistochemistry (IHC)
(Anti- HSD11B2 antibody, IHC(P)IHC(P): Mouse Pancreas Tissue)
Immunohistochemistry (IHC)
(Anti- HSD11B2 antibody, IHC(P)IHC(P): Rat Pancreas Tissue)
Immunohistochemistry (IHC)
(Anti- HSD11B2 antibody, IHC(P)IHC(P): Rat Pancreas Tissue)
Immunohistochemistry (IHC)
(Anti- HSD11B2 antibody, IHC(P)IHC(P): Human Placenta Tissue)
Immunohistochemistry (IHC)
(Anti- HSD11B2 antibody, IHC(P)IHC(P): Human Placenta Tissue)
Background: Corticosteroid 11-beta-dehydrogenase isozyme 2, also known as 11-beta-hydroxysteroid dehydrogenase 2, is an enzyme that in humans is encoded by the HSD11B2 gene. There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
NCBI and Uniprot Product Information
NCBI Description
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
Uniprot Description
HSD11B2: Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME). An autosomal recessive form of low-renin hypertension. It is usually diagnosed within the first years of life and is characterized by polyuria and polydipsia, failure to thrive, hypernatremia, severe hypertension with low renin and aldosterone levels, profound hypokalemia with metabolic alkalosis, and most often nephrocalcinosis. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: EC 1.1.1.-; Lipid Metabolism - androgen and estrogen; Oxidoreductase; Lipid Metabolism - C21-steroid hormone
Chromosomal Location of Human Ortholog: 16q22
Cellular Component: endoplasmic reticulum membrane
Molecular Function: 11-beta-hydroxysteroid dehydrogenase activity; NAD binding; steroid binding
Biological Process: aldosterone mediated regulation of blood volume; female pregnancy; glucocorticoid biosynthetic process; response to drug; response to food; response to glucocorticoid stimulus; response to hypoxia; response to insulin stimulus
Disease: Apparent Mineralocorticoid Excess
Research Articles on HSD11B2
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Product Notes
The HSD11B2 hsd11b2 (Catalog #AAA178156) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-HSD11B2 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HSD11B2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin. Western Blot Concentration: 0.1-0.5ug/ml Immunohistochemistry (IHC) Paraffin Concentration: 0.5-1ug/ml. Researchers should empirically determine the suitability of the HSD11B2 hsd11b2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HSD11B2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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