Goat HPX / Hemopexin Polyclonal Antibody | anti-HPX antibody

Goat Polyclonal to Human HPX / Hemopexin

Cat. Num. AAA243791

• Gene Names: HPX; HX
• Reactivity: Gorilla, Human, Monkey, Orangutan
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: HPX / Hemopexin; Polyclonal Antibody; Goat Polyclonal to Human HPX / Hemopexin; Anti-HPX / Hemopexin Antibody IHC-plus; HPX; Hemopexin; HX; Beta-1B-glycoprotein; Human HPX; anti-HPX antibody

• Host: Goat
• Reactivity: Gorilla, Human, Monkey, Orangutan
• Clonality: Polyclonal
• Specificity: Human HPX / Hemopexin.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 462

• Applicable Applications for anti-HPX antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (3.75 ug/ml); Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
• Target Species: Human
• Immunogen Description: Synthetic peptide C-HGNVAEGETKPDPD from an internal region of human HPX / Hemopexin (NP_000604.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Monkey (100%); Marmoset (86%).
• Immunogen Type: Synthetic peptide
• Immunogen: HPX / Hemopexin antibody was raised against synthetic peptide C-HGNVAEGETKPDPD from an internal region of human HPX / Hemopexin (NP_000604.1). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Monkey (100%); Marmoset (86%).
• Preparation and Storage: Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-Hemopexin antibody IHC of human placenta, serum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

Immunohistochemistry (IHC)

(Anti-Hemopexin antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 11321561
• NCBI GeneID: 3263
• NCBI Accession #: NP_000604.1
• NCBI GenBank Nucleotide #: NM_000613.2
• UniProt Accession #: P02790; B2R957
• Molecular Weight: 51,676 Da
• NCBI Official Full Name: hemopexin
• NCBI Official Synonym Full Names: hemopexin
• NCBI Official Symbol: HPX
• NCBI Official Synonym Symbols: HX
• NCBI Protein Information: hemopexin; beta-1B-glycoprotein
• UniProt Protein Name: Hemopexin
• Protein Family: Hemopexin
• UniProt Gene Name: HPX
• UniProt Entry Name: HEMO_HUMAN

NCBI Description

This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]

Uniprot Description

HPX: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. Belongs to the hemopexin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.5-p15.4

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; metal ion binding; heme transporter activity

Biological Process: receptor-mediated endocytosis; positive regulation of humoral immune response mediated by circulating immunoglobulin; positive regulation of immunoglobulin production; positive regulation of tyrosine phosphorylation of Stat1 protein; heme transport; viral reproduction; hemoglobin metabolic process; cellular iron ion homeostasis; heme metabolic process