Western Blot (WB)
(Western blot analysis of extracts from rat muscle tissue, using Phospho-HPD(Thr382) Antibody. Lane1 was treated with phospho-blocking peptide, Lane2 was treated with non-phospho-blocking peptide.)
Rabbit HPD Polyclonal Antibody | anti-HPD antibody
Phospho-HPD (Thr382) Antibody
Predicted Reactivity: Rabbit (100%)
Predicted Reactivity: Rabbit (100%)
Peptide ELISA: 1:20,000-1:40,000
Western Blot (WB)
(Western blot analysis of extracts from rat muscle tissue, using Phospho-HPD(Thr382) Antibody. Lane1 was treated with phospho-blocking peptide, Lane2 was treated with non-phospho-blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from rat muscle tissue, using Phospho-HPD(Thr382) Antibody. Lane1 was treated with phospho-blocking peptide, Lane2 was treated with non-phospho-blocking peptide.)
Western Blot (WB)
(Western blot analysis of extracts from various samples, using Phospho-HPD(Thr382) Antibody.Lane 1: Mouse brain lysates;Lane 2: Rat brain lysates;Lane 3: Rat muscle lysates;Lane 4: Rat muscle lysates treated with blocking peptide;)
Western Blot (WB)
(Western blot analysis of extracts from various samples, using Phospho-HPD(Thr382) Antibody.Lane 1: Mouse brain lysates;Lane 2: Rat brain lysates;Lane 3: Rat muscle lysates;Lane 4: Rat muscle lysates treated with blocking peptide;)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Uniprot Description
HPD: Key enzyme in the degradation of tyrosine. Defects in HPD are the cause of tyrosinemia type 3 (TYRO3). TYRO3 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation. Defects in HPD are a cause of hawkinsinuria (HAWK). HAWK is an inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine. Belongs to the 4HPPD family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.13.11.27; Cofactor and Vitamin Metabolism - ubiquinone and other terpenoid-quinone biosynthesis; Amino Acid Metabolism - phenylalanine; Oxidoreductase; Amino Acid Metabolism - tyrosine
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: cytosol
Molecular Function: 4-hydroxyphenylpyruvate dioxygenase activity; metal ion binding
Biological Process: L-phenylalanine catabolic process; tyrosine catabolic process
Disease: Hawkinsinuria; Tyrosinemia, Type Iii
Research Articles on HPD
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Product Notes
The HPD hpd (Catalog #AAA9614528) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-HPD (Thr382) Antibody reacts with Human, Mouse, Rat Predicted Reactivity: Rabbit (100%) and may cross-react with other species as described in the data sheet. AAA Biotech's HPD can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Peptide ELISA (EIA). WB: 1:1000-3000 Peptide ELISA: 1:20,000-1:40,000. Researchers should empirically determine the suitability of the HPD hpd for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HPD, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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