Rabbit anti-Human HOXC6 Polyclonal Antibody | anti-HOXC6 antibody

HOXC6, CT (HOXC6, HOX3C, Homeobox protein Hox-C6, Homeobox protein CP25, Homeobox protein HHO.C8, Homeobox protein Hox-3C) (FITC)

Cat. Num. AAA6308037

• Gene Names: HOXC6; CP25; HOX3; HOX3C; HHO.C8
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay, Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: HOXC6; Polyclonal Antibody; CT (HOXC6; HOX3C; Homeobox protein Hox-C6; Homeobox protein CP25; Homeobox protein HHO.C8; Homeobox protein Hox-3C) (FITC); Homeobox protein Hox-3C; anti-HOXC6 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-HOXC6 antibody: Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)
• Application Notes: FC/FACS: 1:10-50; FLISA: 1:1,000; WB: 1:100-500; Applications are based on unconjugated antibody.
• Immunogen: HOXC6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-238 amino acids from the C-terminal region of human HOXC6.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(HOXC6 Antibody (C-term) western blot analysis in PC-3 cell line lysates (35ug/lane).This demonstrates the HOXC6 antibody detected the HOXC6 protein (arrow).)

Flow Cytometry (FC/FACS)

(HOXC6 Antibody (C-term) flow cytometric analysis of U251 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.)

Related Product Information for anti-HOXC6 antibody

This protein belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon.

Product Categories/Family for anti-HOXC6 antibody

Antibodies; Transcription Factors; Zinc; Ring; Homeobox

References

Zhang, X., et al. J. Cell. Mol. Med. 11(2):299-306(2007). Hori, Y., et al. PLoS Med. 2 (4), E103 (2005). Ramachandran, S., et al. Oncogene 24(1):188-198(2005).

NCBI and Uniprot Product Information

• NCBI GI #: 4758554
• NCBI GeneID: 3223
• NCBI Accession #: NP_004494.1
• NCBI GenBank Nucleotide #: NM_004503.3
• UniProt Accession #: P09630; Q6DK09; B2RBV2
• Molecular Weight: 26,915 Da
• NCBI Official Full Name: homeobox protein Hox-C6 isoform 1
• NCBI Official Synonym Full Names: homeobox C6
• NCBI Official Symbol: HOXC6
• NCBI Official Synonym Symbols: CP25; HOX3; HOX3C; HHO.C8
• NCBI Protein Information: homeobox protein Hox-C6; homeo box 3C; homeo box C6; homeo box C8 protein; homeobox protein CP25; homeobox protein HHO.C8; homeobox protein Hox-3C
• UniProt Protein Name: Homeobox protein Hox-C6
• Protein Family: Homeobox protein
• UniProt Gene Name: HOXC6
• UniProt Synonym Gene Names: HOX3C
• UniProt Entry Name: HXC6_HUMAN

NCBI Description

This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons. [provided by RefSeq, Jul 2008]

Uniprot Description

HOXC6: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Antp homeobox family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: sequence-specific DNA binding; transcription corepressor activity; transcription factor activity

Biological Process: anterior/posterior pattern formation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; embryonic skeletal development; multicellular organismal development