Western Blot (WB)
(Mouse Hoxa2 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Hoxa2 antibody detected the Hoxa2 protein (arrow).)
Rabbit Hoxa2 Polyclonal Antibody | anti-Hoxa2 antibody
Mouse Hoxa2 Antibody (Center)
Western Blot (WB)
(Mouse Hoxa2 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Hoxa2 antibody detected the Hoxa2 protein (arrow).)
Western Blot (WB)
(Mouse Hoxa2 Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Hoxa2 antibody detected the Hoxa2 protein (arrow).)
Liu, Z.R., et al. Brain Res. Bull. 82 (1-2), 74-82 (2010) :
Tavella, S., et al. Differentiation 79(3):194-202(2010)
Yallowitz, A.R., et al. Dev. Biol. 335(1):156-165(2009)
Voss, A.K., et al. Dev. Cell 17(5):674-686(2009)
NCBI and Uniprot Product Information
NCBI Description
This gene is located in a cluster of developmentally and temporally regulated genes on chromosome 6 encoding proteins involved in pattern formation. These proteins contain a characteristic DNA-binding motif called a homeodomain and function in transcriptional regulation. There are four distinct clusters of related genes on chromosomes 2, 6, 11, and 15. The protein encoded by this gene is expressed in rhombomere 2 and is important for hindbrain formation in the early embryo. [provided by RefSeq, Mar 2013]
Uniprot Description
HOXA2: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Defects in HOXA2 are a cause of microtia hearing impairment and cleft palate (MHICP). Microtia is a congenital deformity of the outer ear and occurs in approximately one in 8'000-10'000 births. It is characterized by a small, abnormally shaped outer ear. It can be unilateral or bilateral. Syndromic forms of microtia occur in conjunction with other abnormalities. The most common associated malformations is the cleft palate, a congenital fissure of the soft and/or hard palate due to faulty fusion. Defects in HOXA2 are a cause of autosomal- recessive bilateral microtia, mixed symmetrical severe to profound hearing impairment and partial cleft palate. Belongs to the Antp homeobox family. Proboscipedia subfamily.
Protein type: DNA-binding
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; cell fate commitment; transcription, DNA-dependent; multicellular organismal development; motor axon guidance; middle ear morphogenesis; negative regulation of transcription from RNA polymerase II promoter; embryonic viscerocranium morphogenesis; cell fate determination; pattern specification process; osteoblast development; embryonic skeletal morphogenesis; segment specification; anterior/posterior pattern formation; negative regulation of neuron differentiation; regulation of transcription, DNA-dependent; dorsal/ventral pattern formation; rhombomere 2 development; positive regulation of transcription from RNA polymerase II promoter; negative regulation of osteoblast differentiation; rhombomere 3 morphogenesis; rhombomere 3 development; brain segmentation
Research Articles on Hoxa2
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Product Notes
The Hoxa2 hoxa2 (Catalog #AAA9210808) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 190-217. The Mouse Hoxa2 Antibody (Center) reacts with Mouse (Predicted Reactivity: Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's Hoxa2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Hoxa2 hoxa2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Hoxa2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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