Rabbit anti-Human, Mouse HOOK2 Polyclonal Antibody | anti-HOOK2 antibody

HOOK2 Antibody

Cat. Num. AAA7044545

• Gene Names: HOOK2; HK2
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: HOOK2; Polyclonal Antibody; HOOK2 Antibody; Protein Hook homolog 2; h-hook2; hHK2; anti-HOOK2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 717

• Applicable Applications for anti-HOOK2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Species: Human
• Immunogen: Recombinant human Protein Hook homolog 2 protein (C-280AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49980 / sc-49976 / sc-98430
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB)

(Western blotAll lanes: HOOK2 antibody at 3.91 ug/mlLane 1: Mouse large intestine tissueLane 2: Mouse small intestine tissueLane 3: Mouse stomach tissueLane 4: Mouse liver tissueLane 5: A431 whole cell lysateSecondaryGoat polyclonal to rabbit IgG at 1/10000 dilutionPredicted band size: 83 kDaObserved band size: 83,60 kDa)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver tissue using MBS7044545 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7044545 at dilution of 1:100)

Related Product Information for anti-HOOK2 antibody

Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones.

NCBI and Uniprot Product Information

• NCBI GI #: 154354987
• NCBI GeneID: 29911
• NCBI Accession #: NP_001093646.1
• NCBI GenBank Nucleotide #: NM_001100176.1
• UniProt Accession #: Q96ED9; O60562
• Molecular Weight: 83,022 Da
• NCBI Official Full Name: protein Hook homolog 2 isoform 2
• NCBI Official Synonym Full Names: hook microtubule tethering protein 2
• NCBI Official Symbol: HOOK2
• NCBI Official Synonym Symbols: HK2
• NCBI Protein Information: protein Hook homolog 2
• UniProt Protein Name: Protein Hook homolog 2
• Protein Family: Protein Hook
• UniProt Gene Name: HOOK2
• UniProt Synonym Gene Names: h-hook2; hHK2
• UniProt Entry Name: HOOK2_HUMAN

NCBI Description

Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[supplied by OMIM, Apr 2004]

Uniprot Description

HOOK2: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. Belongs to the hook family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: centrosome

Molecular Function: identical protein binding; protein binding

Biological Process: early endosome to late endosome transport; endocytosis; endosome organization and biogenesis; endosome to lysosome transport; lysosome organization and biogenesis