Rabbit anti-Human HOOK1 Polyclonal Antibody | anti-HOOK1 antibody

Anti-HOOK1 Antibody

Cat. Num. AAA416534

• Gene Names: HOOK1; HK1
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: Affinity purified
• Synonyms: HOOK1; Polyclonal Antibody; Anti-HOOK1 Antibody; anti-HOOK1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 300

• Applicable Applications for anti-HOOK1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: ELISA titer: 1:20,000-1:80,000; Western blot analysis: 1:500-1:1,000; Immunohistochemistry: 1:100-1:500; Optimal dilutions/concentrations should be determined by the end user
• Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Testing Data

Related Product Information for anti-HOOK1 antibody

This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

NCBI and Uniprot Product Information

• NCBI GI #: 79149813
• NCBI GeneID: 51361
• Molecular Weight: 80,021 Da
• NCBI Official Full Name: HOOK1 protein, partial
• NCBI Official Synonym Full Names: hook microtubule-tethering protein 1
• NCBI Official Symbol: HOOK1
• NCBI Official Synonym Symbols: HK1
• NCBI Protein Information: protein Hook homolog 1; h-hook1; hHK1; hook homolog 1
• UniProt Protein Name: Protein Hook homolog 1
• Protein Family: Protein Hook
• UniProt Gene Name: HOOK1
• UniProt Entry Name: HOOK1_HUMAN

NCBI Description

This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

HOOK1: Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton. Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Belongs to the hook family.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 1p32.1

Cellular Component: microtubule

Molecular Function: identical protein binding; protein binding; actin binding

Biological Process: protein transport; endosome organization and biogenesis; early endosome to late endosome transport; lysosome organization and biogenesis; multicellular organismal development; endosome to lysosome transport; spermatid development