Rabbit HMGA1 Polyclonal Antibody | anti-HMGA1 antibody

HMGA1 Antibody

Cat. Num. AAA9430475

• Gene Names: HMGA1; HMG-R; HMGIY; HMGA1A
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: HMGA1; Polyclonal Antibody; HMGA1 Antibody; HMG-R; HMGIY; HMGA1A; anti-HMGA1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: The antibody detects endogenous levels of total HMGA1 protein.
• Purity/Purification: Antigen affinity purification
• Form/Format: pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
• Concentration: 0.6 mg/mL (varies by lot)
• Sequence Length: 96

• Applicable Applications for anti-HMGA1 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-200
• Immunogen: Synthetic peptide of human HMGA1
• Immunogen Type: Peptide
• Preparation and Storage: Store at -20 degree C.

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using 47493(HMGA1 Antibody) at dilution 1/30.(Original magnification: 200))

Immunohistochemistry (IHC)

(The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using 47493(HMGA1 Antibody) at dilution 1/30.(Original magnification: 200))

Related Product Information for anti-HMGA1 antibody

This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene.

Product Categories/Family for anti-HMGA1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 977380206
• NCBI GeneID: 3159
• NCBI Accession #: NP_001306006.1
• NCBI GenBank Nucleotide #: NM_001319077.1
• UniProt Accession #: P17096; P10910; Q5T6U9; Q9UKB0
• Molecular Weight: 10,679 Da
• NCBI Official Full Name: high mobility group protein HMG-I/HMG-Y isoform b
• NCBI Official Synonym Full Names: high mobility group AT-hook 1
• NCBI Official Symbol: HMGA1
• NCBI Official Synonym Symbols: HMG-R; HMGIY; HMGA1A
• NCBI Protein Information: high mobility group protein HMG-I/HMG-Y
• UniProt Protein Name: High mobility group protein HMG-I/HMG-Y
• Protein Family: High mobility group protein
• UniProt Gene Name: HMGA1
• UniProt Synonym Gene Names: HMGIY; HMG-I(Y); High mobility group protein A1

NCBI Description

This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]

Uniprot Description

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.