Goat anti-Human HMG-CoA Reductase Polyclonal Antibody | anti-Hmgcr antibody

HMG-CoA Reductase (3-hydroxy-3-methylglutaryl-Coenzyme A reductase, LDLCQ3, HMGCR)

Cat. Num. AAA619782

• Gene Names: Hmgcr; BcDNA:LD15354; bro1; bs32f05.y1; CG10367; clb; Clb; DmelCG10367; DmHMG-CoAr; Hmg; HmG-CoAR; hmgc; HMGCoAr; HMGCoAR; HMGCoARr; hmgcr; HMGCR; HMGCR_Dm; hmgrc; l(3)01152
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: HMG-CoA Reductase; Polyclonal Antibody; HMG-CoA Reductase (3-hydroxy-3-methylglutaryl-Coenzyme A reductase; LDLCQ3; HMGCR); Anti -HMG-CoA Reductase (3-hydroxy-3-methylglutaryl-Coenzyme A reductase; anti-Hmgcr antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human HMG-CoA Reductase.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-Hmgcr antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA:1:8000
• Immunogen: Synthetic peptide corresponding to C-ADPSPQNSTADTSK, from the internal region of human HMG-CoA Reductase (NP_000850).
• Positive Control: Human Brain (Cerebellum), Liver, Skeletal Muscle and Adipose lysates
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-Hmgcr antibody

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-Hmgcr antibody

Antibodies; Abs to CoEnzyme A

NCBI and Uniprot Product Information

• NCBI GI #: 281362379
• NCBI GeneID: 42803
• NCBI Accession #: NP_001163703.1
• NCBI GenBank Nucleotide #: NM_001170232.1
• UniProt Accession #: P14773; Q9VCI8; A4V3A8
• Molecular Weight: 98,317 Da
• NCBI Official Full Name: HMG coenzyme A reductase, isoform C
• NCBI Official Synonym Full Names: HMG Coenzyme A reductase
• NCBI Official Symbol: Hmgcr
• NCBI Official Synonym Symbols: BcDNA:LD15354; bro1; bs32f05.y1; CG10367; clb; Clb; DmelCG10367; DmHMG-CoAr; Hmg; HmG-CoAR; hmgc; HMGCoAr; HMGCoAR; HMGCoARr; hmgcr; HMGCR; HMGCR_Dm; hmgrc; l(3)01152
• NCBI Protein Information: CG10367 gene product from transcript CG10367-RA; HMG coenzyme A reductase, isoform A; CG10367-PA; Hmgcr-PA; columbus; HMGCo-A reductase; 3-hydroxy-3-methylglutaryl coenzyme A reductase; Hmg-CoA-reductase; HMG-CoA reductase; HMGCoA reductase; 3-Hydroxy-3-Methylglutaryl CoA reductase; HMG coenzyme A reductase, isoform B; CG10367-PB; Hmgcr-PB; HMG coenzyme A reductase, isoform C; CG10367-PC; Hmgcr-PC
• UniProt Protein Name: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
• Protein Family: HMG-CoA reductase inhibitor
• UniProt Gene Name: Hmgcr
• UniProt Synonym Gene Names: HmG-CoAR
• UniProt Entry Name: HMDH_DROME

Uniprot Description

Function: Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Ref.4

Catalytic activity: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.

Enzyme regulation: The activity of HMG-CoA-reductase is suppressed by exogenous mevalonate. Ref.1

Pathway: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue specificity: Highly expressed in embryonic gonadal mesoderm, where expression is initially broad, and then becomes restricted to a segmental pattern at stage 11. Expression is then further restricted to a cluster of cells in each of parasegments 10, 11 and 12, corresponding to the developing gonadal mesoderm. Not expressed in pole cells. Ref.4

Sequence similarities: Belongs to the HMG-CoA reductase family.Contains 1 SSD (sterol-sensing) domain.