Rabbit anti-Human, Mouse HIVEP3 Polyclonal Antibody | anti-HIVEP3 antibody

HIVEP3 Antibody

Cat. Num. AAA9630376

• Gene Names: HIVEP3; KRC; KBP1; SHN3; ZAS3; KBP-1; ZNF40C; Schnurri-3
• Reactivity: Human, Mouse
• Applications: ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Synonyms: HIVEP3; Polyclonal Antibody; HIVEP3 Antibody; FLJ16752; Hivep3; Human immunodeficiency virus type I enhancer-binding protein 3; Kappa-B and V(D)J recombination signal sequences-binding protein; Kappa-binding protein 1; KBP-1; KIAA1555; KRC; Schnurri-3; SHN3; Transcription factor HIVEP3; ZEP3_HUMAN; Zinc finger protein ZAS3; ZNF40C; anti-HIVEP3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: HIVEP3 Antibody detects endogenous levels of HIVEP3.
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
• Form/Format: Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-HIVEP3 antibody: ELISA (EIA)(peptide)
• Application Notes: ELISA(peptide): 1:20000-1:40000
• Immunogen: A synthesized peptide derived from human HIVEP3.
• Conjugation: Unconjugated
• Similarity: The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures.
• Post Translational Modifications: Phosphorylated on threonine and serine residues.
• Subunit Structure: Interacts with TRAF1 AND TRAF2 as well as with JUN. Forms a multimeric complex with RUNX2 and E3 ubiquitin ligase WWP1 (By similarity).
• Function: Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Product Categories/Family for anti-HIVEP3 antibody

Cytoplasm; Nucleus; Primary

NCBI and Uniprot Product Information

• NCBI GI #: 189181750
• NCBI GeneID: 59269
• NCBI Accession #: NP_001121186.1
• NCBI GenBank Nucleotide #: NM_001127714.2
• UniProt Accession #: Q5T1R4; Q5T1R5; Q9BZS0; Q9HCL7; A7YY91
• Molecular Weight: 259,336 Da
• NCBI Official Full Name: transcription factor HIVEP3 isoform b
• NCBI Official Synonym Full Names: human immunodeficiency virus type I enhancer binding protein 3
• NCBI Official Symbol: HIVEP3
• NCBI Official Synonym Symbols: KRC; KBP1; SHN3; ZAS3; KBP-1; ZNF40C; Schnurri-3
• NCBI Protein Information: transcription factor HIVEP3
• UniProt Protein Name: Transcription factor HIVEP3
• Protein Family: Transcription factor
• UniProt Gene Name: HIVEP3
• UniProt Synonym Gene Names: KBP1; KIAA1555; KRC; ZAS3; KBP-1
• UniProt Entry Name: ZEP3_HUMAN

NCBI Description

This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011]

Uniprot Description

HIVEP3: Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down- regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1p34

Cellular Component: cytoplasm; nucleus

Molecular Function: DNA binding; metal ion binding

Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent