Product Categories/Family for anti-HTATIP antibody
References
1. Cai, Y., et al., J. Biol. Chem. 280(14):13665-13670 (2005). 2. Patel, J.H., et al., Mol. Cell. Biol. 24(24):10826-10834 (2004). 3. Legube, G., et al., J. Biol. Chem. 279(43):44825-44833 (2004). 4. Franzese, O., et al., Cell Death Differ. 11(7):782-784 (2004). 5. Taubert, S., et al., Mol. Cell. Biol. 24(10):4546-4556 (2004). 6.Yamagata K, et al. Biochem Biophys Res Commun. 2009 Dec 25;390(4):1355-60. (E-pub).
Uniprot Description
Tip60: a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described.
Protein type: Nucleolus; Nuclear receptor co-regulator; EC 2.3.1.48; Acetyltransferase
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: nucleoplasm; transcription factor complex; NuA4 histone acetyltransferase complex; perinuclear region of cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: protein binding; histone acetyltransferase activity; androgen receptor binding; metal ion binding; transcription coactivator activity; protein complex binding
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; viral reproduction; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; negative regulation of interleukin-2 production; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; double-strand break repair; regulation of growth; androgen receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; response to ionizing radiation; histone acetylation; negative regulation of transcription, DNA-dependent
Product Notes
The HTATIP kat5 (Catalog #
AAA6480881) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HIV-1 Tat Interacting Protein, 60kD, NT (HTATIP, HTATIP1, cPLA2-interacting Protein, ESA1, PLIP, TIP60) (MaxLight 405) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HIV-1 Tat Interacting Protein can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:100-1:500 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the HTATIP kat5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"HIV-1 Tat Interacting Protein, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
details on this or any of our
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