Western Blot (WB)
(Western Blot analysis of SKOV3 cells with Phospho-Histone H1 (Thr17) Polyclonal Antibody at dilution of 1:1000)
Rabbit Histone H1 Polyclonal Antibody | anti-HIST1H1B antibody
Phospho-Histone H1 (Thr17) Polyclonal Antibody
IHC: 1:100-1:300
IF: 1:200-1:1000
ELISA: 1:10000
Western Blot (WB)
(Western Blot analysis of SKOV3 cells with Phospho-Histone H1 (Thr17) Polyclonal Antibody at dilution of 1:1000)
Western Blot (WB)
(Western Blot analysis of SKOV3 cells with Phospho-Histone H1 (Thr17) Polyclonal Antibody at dilution of 1:1000)
NCBI and Uniprot Product Information
Observed Molecular Weight: 31kDa
NCBI Description
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
Uniprot Description
H1B: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. Belongs to the histone H1/H5 family.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 6p22.1
Cellular Component: extracellular exosome; nuclear chromatin; nuclear heterochromatin; nucleosome; nucleus
Molecular Function: chromatin DNA binding; histone deacetylase binding; protein binding; RNA binding
Biological Process: chromatin organization; establishment of protein localization to chromatin; negative regulation of transcription from RNA polymerase II promoter; nucleosome assembly; positive regulation of cell growth; positive regulation of histone H3-K9 methylation; protein stabilization
Research Articles on HIST1H1B
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Product Notes
The HIST1H1B hist1h1b (Catalog #AAA2548846) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Phospho-Histone H1 (Thr17) Polyclonal Antibody reacts with Human, Mouse, Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's Histone H1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), ELISA (EIA). WB: 1:500-1:2000 IHC: 1:100-1:300 IF: 1:200-1:1000 ELISA: 1:10000. Researchers should empirically determine the suitability of the HIST1H1B hist1h1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Histone H1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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