Western Blot (WB)
(Western Blot: Sample: Porcine Kidney Tissue.)
Rabbit anti-Human Histone Deacetylase 6 (HDAC6) Polyclonal Antibody | anti-HDAC6 antibody
Polyclonal Antibody to Histone Deacetylase 6 (HDAC6)
MGHHHHHHSGSEF-VLADT YDSVYLHPNS YSCACLASGS VLRLVDAVLG AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ KHRIRRVLIV DWDVHHGQGT QFTFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGFGQG QGYTINVPWN QVGMRDADYI AAFLHVLLPV ALEFQPQLVL VAAGFDAL
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Porcine Kidney Tissue.)
Western Blot (WB)
(Western Blot: Sample: Porcine Kidney Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant HDAC6, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant HDAC6, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Kidney Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Kidney Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Cancer Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Liver Cancer Tissue.)
NCBI and Uniprot Product Information
NCBI Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
Uniprot Description
HDAC6: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Interacts with CBFA2T3, HDAC11 and SIRT2. Interacts with F-actin. Interacts with BBIP10. Under proteasome impairment conditions, interacts with UBD via its histone deacetylase 1 and UBP-type zinc-finger regions. Interacts with CYLD. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily.
Protein type: Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: Xp11.23
Cellular Component: aggresome; axon; caveola; cell leading edge; cytoplasm; cytoplasmic microtubule; cytosol; dendrite; dynein complex; histone deacetylase complex; inclusion body; microtubule; microtubule associated complex; multivesicular body; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm
Molecular Function: actin binding; alpha-tubulin binding; beta-catenin binding; beta-tubulin binding; enzyme binding; histone deacetylase activity; histone deacetylase binding; Hsp90 protein binding; microtubule binding; misfolded protein binding; NAD-dependent histone deacetylase activity (H3-K14 specific); polyubiquitin modification-dependent protein binding; protein binding; tau protein binding; tubulin deacetylase activity; ubiquitin binding; ubiquitin protein ligase binding; zinc ion binding
Biological Process: autophagy; cellular response to hydrogen peroxide; cellular response to topologically incorrect protein; collateral sprouting; histone deacetylation; intracellular protein transport; lysosome localization; misfolded or incompletely synthesized protein catabolic process; mitochondrion localization; negative regulation of hydrogen peroxide metabolic process; negative regulation of microtubule depolymerization; negative regulation of oxidoreductase activity; negative regulation of protein complex disassembly; negative regulation of proteolysis; negative regulation of transcription, DNA-dependent; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; positive regulation of chaperone-mediated protein complex assembly; positive regulation of epithelial cell migration; positive regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of receptor biosynthetic process; positive regulation of signal transduction; protein complex disassembly; protein deacetylation; protein polyubiquitination; regulation of autophagy; regulation of fat cell differentiation; regulation of gene expression, epigenetic; regulation of macroautophagy; regulation of protein stability; regulation of receptor activity; response to misfolded protein; response to organic substance; response to toxin; transcription, DNA-dependent; tubulin deacetylation; ubiquitin-dependent protein catabolic process via the multivesicular body pathway
Disease: Chondrodysplasia With Platyspondyly, Distinctive Brachydactyly, Hydrocephaly, And Microphthalmia
Research Articles on HDAC6
Similar Products
Product Notes
The HDAC6 hdac6 (Catalog #AAA2005904) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Histone Deacetylase 6 (HDAC6) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Histone Deacetylase 6 (HDAC6) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the HDAC6 hdac6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below. MGHHHHHHSG SEF-VLADT YDSVYLHPNS YSCACLASGS VLRLVDAVLG AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ KHRIRRVLIV DWDVHHGQGT QFTFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGFGQG QGYTINVPWN QVGMRDADYI AAFLHVLLPV ALEFQPQLVL VAAGFDAL. It is sometimes possible for the material contained within the vial of "Histone Deacetylase 6 (HDAC6), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
