Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human colon cancer using at dilution of 1:20.)
Rabbit anti-Human Histone deacetylase 4 Polyclonal Antibody | anti-HDAC4 antibody
Histone deacetylase 4 Polyclonal Antibody
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human colon cancer using at dilution of 1:20.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded human colon cancer using at dilution of 1:20.)
NCBI and Uniprot Product Information
Uniprot Description
HDAC4: a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Protein type: Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: cytoplasm; histone deacetylase complex; nucleoplasm; nucleus; transcriptional repressor complex
Molecular Function: histone deacetylase activity; histone deacetylase binding; potassium ion binding; protein binding; protein deacetylase activity; sequence-specific DNA binding; transcription activator binding; transcription factor binding; zinc ion binding
Biological Process: B cell activation; B cell differentiation; cardiac muscle hypertrophy; chromatin remodeling; histone deacetylation; inflammatory response; negative regulation of glycolysis; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nervous system development; positive regulation of cell proliferation; positive regulation of protein sumoylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of gene expression, epigenetic; regulation of protein binding; response to denervation involved in regulation of muscle adaptation
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Product Notes
The HDAC4 hdac4 (Catalog #AAA9415894) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Histone deacetylase 4 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Histone deacetylase 4 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Immunohistochemistry: 1:20 - 1:200. Researchers should empirically determine the suitability of the HDAC4 hdac4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Histone deacetylase 4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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