Rabbit anti-Human Histone acetyltransferase KAT5 Polyclonal Antibody | anti-KAT5 antibody

Rabbit anti-human Histone acetyltransferase KAT5 polyclonal Antibody, FITC

Cat. Num. AAA1490223

• Gene Names: KAT5; TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1
• Reactivity: Human
• Applications: ELISA
• Purity: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Synonyms: Histone acetyltransferase KAT5; Polyclonal Antibody; Rabbit anti-human Histone acetyltransferase KAT5 polyclonal Antibody; FITC; 60 kDa Tat-interactive protein; Histone acetyltransferase HTATIP; Lysine acetyltransferase 5; cPLA(2)-interacting protein; KAT5; HTATIP; TIP60; anti-KAT5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Caprylic Acid Ammonium Sulfate Precipitation Purified
• Sequence Length: 494

• Applicable Applications for anti-KAT5 antibody: ELISA (EIA)
• Storage Buffer: Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
• Conjugate: FITC
• Immunogen: Recombinant human Histone acetyltransferase KAT5
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-5725 / sc-5727 / sc-25378
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-KAT5 antibody

Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.

NCBI and Uniprot Product Information

• NCBI GI #: 332205931
• NCBI GeneID: 10524
• NCBI Accession #: NP_001193762.1
• NCBI GenBank Nucleotide #: NM_001206833.1
• UniProt Accession #: Q92993; O95624; Q13430; Q17RW5; Q561W3; Q6GSE8; Q9BWK7; B4E3C7; C9JL99
• Molecular Weight: 56,292 Da
• NCBI Official Full Name: histone acetyltransferase KAT5 isoform 4
• NCBI Official Synonym Full Names: K(lysine) acetyltransferase 5
• NCBI Official Symbol: KAT5
• NCBI Official Synonym Symbols: TIP; ESA1; PLIP; TIP60; cPLA2; HTATIP; ZC2HC5; HTATIP1
• NCBI Protein Information: histone acetyltransferase KAT5
• UniProt Protein Name: Histone acetyltransferase KAT5
• Protein Family: Histone acetyltransferase
• UniProt Gene Name: KAT5
• UniProt Synonym Gene Names: HTATIP; TIP60; Tip60; HIV-1 Tat interactive protein
• UniProt Entry Name: KAT5_HUMAN

NCBI Description

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Description

Tip60: a histone acetyl transferase (HAT) of the MYST family. Originally isolated as an HIV-1 TAT-interactive protein. Plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating nuclear proteins. Plays a role in DNA repair and apoptosis. Three splice variants have been described.

Protein type: EC 2.3.1.48; Nucleolus; Nuclear receptor co-regulator; Acetyltransferase

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: NuA4 histone acetyltransferase complex; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; transcription factor complex

Molecular Function: acetyltransferase activity; androgen receptor binding; histone acetyltransferase activity; metal ion binding; protein binding; transcription coactivator activity

Biological Process: androgen receptor signaling pathway; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; double-strand break repair via nonhomologous end joining; double-strand break repair via synthesis-dependent strand annealing; establishment and/or maintenance of chromatin architecture; histone acetylation; negative regulation of interleukin-2 production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; proteasomal ubiquitin-dependent protein catabolic process; regulation of growth; response to ionizing radiation; transcription, DNA-dependent; viral reproduction