Western Blot (WB)
(Western blot analysis HIPK1/2/3 (Phospho-Tyr352/361/359) using TNF-a treated A2780 whole cell lysates)
Rabbit HIPK1/2/3 Polyclonal Antibody | anti-HIPK1/2/3 antibody
HIPK1/2/3 (Phospho-Tyr352/361/359) Antibody
Western Blot (WB)
(Western blot analysis HIPK1/2/3 (Phospho-Tyr352/361/359) using TNF-a treated A2780 whole cell lysates)
Western Blot (WB)
(Western blot analysis HIPK1/2/3 (Phospho-Tyr352/361/359) using TNF-a treated A2780 whole cell lysates)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
HIPK1: homeodomain interacting protein kinase 1 is a CMGC kinase of the DYRK family. May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Expression elevated in many breast cancer cell lines. Null mice are resistant to carcinogens. Binds the p53 tumor suppressor. 4 alternatively spliced isoforms of the human protein have been described.
Protein type: CMGC group; DYRK family; EC 2.7.11.1; HIPK subfamily; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component: cytoplasm; nucleoplasm; nucleus
Molecular Function: protein binding
Biological Process: eye development; positive regulation of angiogenesis
Research Articles on HIPK1/2/3
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Product Notes
The HIPK1/2/3 hipk1 (Catalog #AAA9416595) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HIPK1/2/3 (Phospho-Tyr352/361/359) Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HIPK1/2/3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:1000. Researchers should empirically determine the suitability of the HIPK1/2/3 hipk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HIPK1/2/3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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