Rabbit HIP1 Polyclonal Antibody | anti-HIP1 antibody

HIP1-Specific Rabbit Polyclonal

Cat. Num. AAA7600103

• Gene Names: Hip1; mKIAA4113; 2610109B09Rik; A930014B11Rik; E130315I21Rik
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: HIP1; Polyclonal Antibody; HIP1-Specific Rabbit Polyclonal; anti-HIP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 1029

• Applicable Applications for anti-HIP1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: Huntingtin interacting protein 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human brain using MBS7600103 (HIP1-Specific antibody) at dilution of 1:100)

Western Blot (WB)

(COLO 320 cells were subjected to SDS PAGE followed by western blot with MBS7600103 (HIP1-Specific antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 225007582
• NCBI GeneID: 215114
• NCBI Accession #: NP_666113.2
• NCBI GenBank Nucleotide #: NM_146001.2
• Molecular Weight: 115,202 Da
• NCBI Official Full Name: huntingtin-interacting protein 1
• NCBI Official Synonym Full Names: huntingtin interacting protein 1
• NCBI Official Symbol: Hip1
• NCBI Official Synonym Symbols: mKIAA4113; 2610109B09Rik; A930014B11Rik; E130315I21Rik
• NCBI Protein Information: huntingtin-interacting protein 1
• UniProt Protein Name: Huntingtin-interacting protein 1
• Protein Family: Histidine permease
• UniProt Gene Name: Hip1
• UniProt Synonym Gene Names: HIP-1; HIP-I
• UniProt Entry Name: HIP1_MOUSE

Uniprot Description

HIP1: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed. Belongs to the SLA2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytoskeletal

Cellular Component: clathrin-coated vesicle; cytoplasm; cytoplasmic vesicle; Golgi apparatus; intracellular membrane-bound organelle; membrane; nucleus

Molecular Function: actin binding; clathrin binding; phosphoinositide binding; phospholipid binding; protein binding

Biological Process: apoptosis; caspase activation; cell differentiation; clathrin cage assembly; endocytosis; positive regulation of receptor-mediated endocytosis; regulation of apoptosis; regulation of transcription, DNA-dependent; transcription, DNA-dependent