Goat Heparin Cofactor II Polyclonal Antibody | anti-SERPIND1 antibody

Heparin Cofactor II (HRP) (HCII)

Cat. Num. AAA614799

• Gene Names: SERPIND1; HC2; LS2; HCF2; HCII; HLS2; D22S673
• Reactivity: Canine, Human, Mouse, Porcine, Rabbit, Rat
• Applications: ELISA
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Heparin Cofactor II; Polyclonal Antibody; Heparin Cofactor II (HRP) (HCII); Anti -Heparin Cofactor II (HRP) (HCII); anti-SERPIND1 antibody

• Host: Goat
• Reactivity: Canine, Human, Mouse, Porcine, Rabbit, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human Heparin Cofactor II.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid, 50% glycerol. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-SERPIND1 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA and Immunoelectrophoresis.
• Immunogen: Heparin Cofactor II isolated from human plasma.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Labeled with horseradish peroxidase (HRP). Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. HRP conjugates are sensitive to light.

Related Product Information for anti-SERPIND1 antibody

Heparin Cofactor II (HCII) is a single chain glycoprotein produced in the liver and circulates in plasma at concentration of 50-100ug/ml (0.8-1.5uM). A member of the SERPIN family of proteinase inhibitors, HCII exhibits a relatively narrow specificity and is only known to inhibit the serine proteinases thrombin and chymotrypsin. The inhibitory activity toward thrombin is accelerated up to 1000-fold in the presence of optimal concentrations of heparin. Unlike Antithrombin, thrombin inhibition by HCII is also enhanced by dermatan sulphate. HCII has an apparent molecular weight of 65,600 daltons and interaction with thrombin results in a covalent 1:1 enzyme-inhibitor complex of 102,600 daltons (1-3).

Product Categories/Family for anti-SERPIND1 antibody

Antibodies; Abs to Coagulation Factors

NCBI and Uniprot Product Information

• NCBI GI #: 183908
• NCBI GeneID: 3053
• UniProt Accession #: P05546; Q6IBZ5; B2RAI1; D3DX34; Q8IVC0
• Molecular Weight: 57,071 Da
• NCBI Official Full Name: heparin cofactor II
• NCBI Official Synonym Full Names: serpin peptidase inhibitor, clade D (heparin cofactor), member 1
• NCBI Official Symbol: SERPIND1
• NCBI Official Synonym Symbols: HC2; LS2; HCF2; HCII; HLS2; D22S673
• NCBI Protein Information: heparin cofactor 2; serpin D1; leuserpin 2; OTTHUMP00000198450; OTTHUMP00000198451; protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
• UniProt Protein Name: Heparin cofactor 2
• Protein Family: Heparin cofactor
• UniProt Gene Name: SERPIND1
• UniProt Synonym Gene Names: HCF2
• UniProt Entry Name: HEP2_HUMAN

NCBI Description

The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq]

Uniprot Description

SERPIND1: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10). A hemostatic disorder characterized by a tendency to recurrent thrombosis. Belongs to the serpin family.

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; heparin binding; endopeptidase inhibitor activity

Biological Process: blood coagulation; chemotaxis

Disease: Heparin Cofactor Ii Deficiency