Rabbit Heat Shock Protein 110 Polyclonal Antibody | anti-Hsph1 antibody

Heat Shock Protein 110 (HSP110)

Cat. Num. AAA621634

• Gene Names: Hsph1; 105kDa; Hsp105; Hsp110; hsp-E7I; AI790491
• Reactivity: Bovine, Hamster, Human, Monkey, Mouse, Rat, Sheep, Yeast
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Heat Shock Protein 110; Polyclonal Antibody; Heat Shock Protein 110 (HSP110); Anti -Heat Shock Protein 110 (HSP110); anti-Hsph1 antibody

• Host: Rabbit
• Reactivity: Bovine, Hamster, Human, Monkey, Mouse, Rat, Sheep, Yeast
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes hamster hsp110. Species Crossreactivity: human, monkey, rat, mouse, bovine, sheep, yeast.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH7.2, 50% glycerol and 0.09% sodium azide.

• Applicable Applications for anti-Hsph1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot:1:1000
• Immunogen: Synthetic peptide derived from the sequence of hamster Hsp110; sequence identical to human and mouse.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-Hsph1 antibody

Hsp110 belongs to a family of large stress proteins known as the Hsp110/SSE Family. The proteins in this family are the most distantly known relatives of the well studied Hsp70 family. They share 30-33% amino acid identity, mostly in the conserved ATP-binding domain (1).

Product Categories/Family for anti-Hsph1 antibody

Antibodies; Abs to Heat Shock Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 114145505
• NCBI GeneID: 15505
• NCBI Accession #: NP_038587.2
• NCBI GenBank Nucleotide #: NM_013559.2
• UniProt Accession #: Q61699; Q3TNS2; Q3UIY8; Q62578; Q62579; Q6A0A5; Q8C430; Q8VCW6
• Molecular Weight: 96,407 Da
• NCBI Official Full Name: heat shock protein 105 kDa
• NCBI Official Synonym Full Names: heat shock 105kDa/110kDa protein 1
• NCBI Official Symbol: Hsph1
• NCBI Official Synonym Symbols: 105kDa; Hsp105; Hsp110; hsp-E7I; AI790491
• NCBI Protein Information: heat shock protein 105 kDa; HSP105 42 C-HSP; 42 degrees C-HSP; heat shock protein 110; heat shock 110 kDa protein; heat shock protein, 105 kDa; heat shock-related 100 kDa protein E7I
• UniProt Protein Name: Heat shock protein 105 kDa
• Protein Family: Heat shock protein
• UniProt Gene Name: Hsph1
• UniProt Synonym Gene Names: Hsp105; Hsp110; Kiaa0201; HSP-E7I
• UniProt Entry Name: HS105_MOUSE

Uniprot Description

HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described.

Protein type: Chaperone; Heat shock protein

Cellular Component: nucleoplasm; microtubule; cytoplasm; extracellular region; cytosol; nucleus

Molecular Function: protein binding; nucleotide binding; ATP binding; alpha-tubulin binding

Biological Process: positive regulation of NK T cell activation; chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; negative regulation of neuron apoptosis; response to unfolded protein