Rabbit CTLA4 Polyclonal Antibody | anti-CTLA4 antibody

CTLA4 Antibody

Cat. Num. AAA5313088

• Gene Names: CTLA4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Purified through a protein A column, followed by peptide affinity purification
• Synonyms: CTLA4; Polyclonal Antibody; CTLA4 Antibody; Affintiy Purified Rabbit Polyclonal CTLA4 Antibody; CTLA4 antibody; CTLA 4 antibody; CTLA-4 antibody; Cytotoxic T-lymphocyte protein 4 antibody; CD152 antibody; N terminal CTLA4 antibody; CD152; anti-CTLA4 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: N-terminal CTLA4 (CD152)
• Purity/Purification: Purified through a protein A column, followed by peptide affinity purification
• Form/Format: Liquid in PBS with 0.09% (W/V) Sodium Azide
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence Length: 223

• Applicable Applications for anti-CTLA4 antibody: ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
• Application Notes: ELISA: 1:1000; IHC: 1:1:50-100; WB: 1:100-500
• Immunogen: CTLA4 antibody (N terminal) was raised in Rabbit using a KLH conjugated synthetic peptide between 57-86 amino acids from the N-terminal region of human IDDM12 as the immunogen
• Preparation and Storage: Store at 2-8 degree C for short periods. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Western Blot (WB)

(Western blot analysis using CTLA4 antibody (N terminal)in WiDr cell lysates (35ug/lane).This demonstrates the CTLA4 antibody detected the CTLA4 protein (arrow))

Immunohistochemistry (IHC)

(Immunohistochemical staining in formalin fixed and paraffin embedded human prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.)

Related Product Information for anti-CTLA4 antibody

CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.

Product Categories/Family for anti-CTLA4 antibody

Immunology

NCBI and Uniprot Product Information

• NCBI GI #: 15778586
• NCBI GeneID: 1493
• NCBI Official Full Name: CTLA4
• NCBI Official Synonym Full Names: cytotoxic T-lymphocyte associated protein 4
• NCBI Official Symbol: CTLA4
• NCBI Official Synonym Symbols: CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3
• NCBI Protein Information: cytotoxic T-lymphocyte protein 4
• Protein Family: Cytotoxic T-lymphocyte protein

NCBI Description

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]