Rabbit anti-Human HDAC9 Polyclonal Antibody | anti-HDAC9 antibody

HDAC9 Antibody

Cat. Num. AAA9204380

• Gene Names: HDAC9; HD7; HD9; HD7b; HDAC; HDRP; MITR; HDAC7; HDAC7B; HDAC9B; HDAC9FL
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: HDAC9; Polyclonal Antibody; HDAC9 Antibody; Histone deacetylase 9; HD9; Histone deacetylase 7B; HD7; HD7b; Histone deacetylase-related protein; MEF2-interacting transcription repressor MITR; HDAC7; HDAC7B; HDRP; KIAA0744; MITR; anti-HDAC9 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Purity/Purification: Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 54% glycerol
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 513

• Applicable Applications for anti-HDAC9 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~ 1:500
• Antigen Type: Synthetic Peptide
• Preparation and Storage: Store at -20 degree C.Stable for 12 months from date of receipt

Western Blot (WB)

(Western blot analysis of lysates from Hela,K562 cell line (from left to right), using HDAC9 Antibody(A1-0639). A1-0639 was diluted at 1:500 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysates at 20ug per lane.)

Product Categories/Family for anti-HDAC9 antibody

Cardiovascular; Signal Transduction

NCBI and Uniprot Product Information

• NCBI GI #: 323423044
• NCBI GeneID: 9734
• NCBI Accession #: NP_001191073.1
• NCBI GenBank Nucleotide #: NM_001204144.1
• UniProt Accession #: Q9UKV0; O94845; O95028; Q2M2R6; A7E2F3; B7Z4I4; B7Z917; B7Z928; B7Z940; C9JS87; E7EX34; F8W9E0
• Molecular Weight: 111297
• NCBI Official Full Name: histone deacetylase 9 isoform 6
• NCBI Official Synonym Full Names: histone deacetylase 9
• NCBI Official Symbol: HDAC9
• NCBI Official Synonym Symbols: HD7; HD9; HD7b; HDAC; HDRP; MITR; HDAC7; HDAC7B; HDAC9B; HDAC9FL
• NCBI Protein Information: histone deacetylase 9
• UniProt Protein Name: Histone deacetylase 9
• UniProt Gene Name: HDAC9
• UniProt Synonym Gene Names: HDAC7; HDAC7B; HDRP; KIAA0744; MITR; HD9; HD7; HD7b
• UniProt Entry Name: HDAC9_HUMAN

NCBI Description

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

HDAC9: a transcriptional regulator of the histone deacetylase family, subfamily 2. Deacetylates lysine residues on the N-terminal part of the core histones H2A, H2B, H3 AND H4. Plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

Protein type: EC 3.5.1.98; Transcription, coactivator/corepressor; Deacetylase

Chromosomal Location of Human Ortholog: 7p21.1

Cellular Component: nucleoplasm; transcription factor complex; histone methyltransferase complex; histone deacetylase complex; cytoplasm; nucleus

Molecular Function: NAD-dependent histone deacetylase activity (H3-K9 specific); protein binding; protein kinase C binding; NAD-dependent histone deacetylase activity (H3-K14 specific); histone deacetylase binding; metal ion binding; protein deacetylase activity; NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; transcription corepressor activity; transcription factor binding

Biological Process: regulation of skeletal muscle fiber development; Notch signaling pathway; transcription, DNA-dependent; B cell activation; cellular response to insulin stimulus; regulation of striated muscle cell differentiation; heart development; B cell differentiation; histone deacetylation; negative regulation of transcription from RNA polymerase II promoter; inflammatory response; negative regulation of transcription, DNA-dependent