Rabbit anti-Human, Mouse CPNE6 Polyclonal Antibody | anti-CPNE6 antibody

CPNE6, NT (CPNE6, Copine-6, Copine VI, Neuronal-copine) (APC)

Cat. Num. AAA6288352

• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: CPNE6; Polyclonal Antibody; NT (CPNE6; Copine-6; Copine VI; Neuronal-copine) (APC); Neuronal-copine; anti-CPNE6 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-CPNE6 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: CPNE6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the N-terminal region of human CPNE6.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(CPNE6 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the CPNE6 antibody detected the CPNE6 protein (arrow).)

Related Product Information for anti-CPNE6 antibody

This gene encodes a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity.

Product Categories/Family for anti-CPNE6 antibody

Antibodies; Neuroscience

References

Caudell, E.G., et al. Biochemistry 39(42):13034-13043(2000). Nakayama, T., et al. FEBS Lett. 453 (1-2), 77-80 (1999): Nakayama, T., et al. J. Neurochem. 72(1):373-379(1999). Nakayama, T., et al. FEBS Lett. 428 (1-2), 80-84 (1998).

NCBI and Uniprot Product Information

• NCBI GI #: 5174421
• NCBI GeneID: 9362
• NCBI Accession #: NP_006023.1
• NCBI GenBank Nucleotide #: NM_006032.3
• UniProt Accession #: O95741; Q53HA6; Q8WVG1; B2RAG6; B7Z1M3; D3DS55; F5GXN1
• Molecular Weight: 67,641 Da
• NCBI Official Full Name: copine-6 isoform 2
• NCBI Official Synonym Full Names: copine VI (neuronal)
• NCBI Official Symbol: CPNE6
• NCBI Protein Information: copine-6; N-copine
• UniProt Protein Name: Copine-6
• Protein Family: Copine
• UniProt Gene Name: CPNE6
• UniProt Synonym Gene Names: N-copine
• UniProt Entry Name: CPNE6_HUMAN

NCBI Description

This gene encodes a member of the copine family. Members of this family are calcium-dependent, phospholipid-binding proteins with C2 domains, two calcium- and phospholipid-binding domains. Through their domain structure and lipid binding capabilities, these proteins may play a role in membrane trafficking. This protein is thought to be brain-specific and has a domain structure of two N-terminal C2 domains and one von Willebrand factor A domain. It may have a role in synaptic plasticity. [provided by RefSeq, Jul 2013]

Uniprot Description

CPNE6: May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties. May have a role in synaptic plasticity. Belongs to the copine family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 14q11.2

Cellular Component: membrane; axon; dendrite

Molecular Function: transporter activity; phosphatidylserine binding; calcium ion binding

Biological Process: vesicle-mediated transport; synaptic transmission; nervous system development; lipid metabolic process