Western Blot (WB)
(HDAC7 Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the HDAC7 antibody detected the HDAC7 protein (arrow).)
Rabbit anti-Human HDAC7 Polyclonal Antibody | anti-HDAC7 antibody
HDAC7 Antibody (C-term)
Western Blot (WB)
(HDAC7 Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the HDAC7 antibody detected the HDAC7 protein (arrow).)
Western Blot (WB)
(HDAC7 Antibody (C-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the HDAC7 antibody detected the HDAC7 protein (arrow).)
Immunohistochemistry (IHC)
(HDAC7 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HDAC7 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(HDAC7 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HDAC7 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
regulation, cell cycle progression, and developmental events.
Histone acetylation/deacetylation alters chromosome structure and
affects transcription factor access to DNA. The protein encoded by
this gene has sequence homology to members of the histone
deacetylase family. This gene is orthologous to mouse HDAC7 gene
whose protein promotes repression mediated via the transcriptional
corepressor SMRT. Alternatively spliced transcript variants
encoding different isoforms have been found for this gene.
Margariti, A., et al. Circ. Res. 106(7):1202-1211(2010)
Hutt, D.M., et al. Nat. Chem. Biol. 6(1):25-33(2010)
Malik, S., et al. Mol. Cell. Biol. 30(2):399-412(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
NCBI and Uniprot Product Information
NCBI Description
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
HDAC7: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Interacts with HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, NCOR1, NCOR2, SIN3A, SIN3B, RBBP4, RBBP7, MTA1L1, SAP30 and MBD3. Interacts with the 14-3-3 protein YWHAE, MEF2A, MEF2B and MEF2C. Interacts with KAT5 and EDNRA. Interacts with KDM5B. Interacts with ZMYND15. Belongs to the histone deacetylase family. HD type 2 subfamily. 10 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.5.1.98; Hydrolase
Chromosomal Location of Human Ortholog: 12q13.1
Cellular Component: nucleoplasm; cytoplasm; histone deacetylase complex; nucleus
Molecular Function: protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); transcription activator binding; protein kinase C binding; NAD-dependent histone deacetylase activity (H3-K14 specific); metal ion binding; chromatin binding; NAD-dependent histone deacetylase activity (H4-K16 specific); protein kinase binding; transcription corepressor activity
Biological Process: intercellular junction assembly; Notch signaling pathway; transcription, DNA-dependent; negative regulation of osteoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; vasculogenesis; negative regulation of interleukin-2 production
Research Articles on HDAC7
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Product Notes
The HDAC7 hdac7 (Catalog #AAA9204828) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 846-875. The HDAC7 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HDAC7 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the HDAC7 hdac7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HDAC7, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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