Testing Data
Rabbit anti-Rat HCN3 Polyclonal Antibody | anti-HCN3 antibody
Anti-HCN3 Antibody
Reactivity
Rat
Applications
Western Blot
Purity
Affinity Purified On Immobilized Antigen.
Synonyms
HCN3; Polyclonal Antibody; Anti-HCN3 Antibody; Orai; anti-HCN3 antibody
Host
Rabbit
Reactivity
Rat
Clonality
Polyclonal
Specificity
Human, rat-identical.
Purity/Purification
Affinity Purified On Immobilized Antigen.
Form/Format
Liquid; PBS, pH 7.4 with 0.05% sodium azide.
Concentration
1ug/ul (varies by lot)
Sequence Length
142
Applicable Applications for anti-HCN3 antibody
Western Blot (WB)
Application Notes
WB: Rat brain lysate (1:200)
Immunogen
Peptide (C)QRATGDGSPRRKGSGSER corresponding to residues 727-744 of rat HCN3 (Accession Q9JKA8).
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
For extended storage, aliquot contents and freeze at-20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Testing Data
Testing Data
Related Product Information for anti-HCN3 antibody
Hyperpolarization-activated cation currents (Ih) appear in the heart and the brain and play a crucial role in controlling electrical pacemaker activity, contributing to biological processes such as heartbeat, sleep-wake cycle and synaptic plasticity.1, 2 The Ih currents are generated by the Hyperpolarization-activated Cyclic Nucleotide-gated cannel family (HCN), which comprises of four homologous members, named HCN1-4. Each HCN subunit consist of six transmembrane domains (TM), a pore region between TM5-TM6 and a binding domain to cyclic nucleotides (CNBD) in the cytoplasmic C-terminus.2 The HCN subunits can form functional homomers and can also co-assemble into functionally heteromers.2 The channels are closely related to each other and share homology of about 60%. However, they differ from each other in their cytoplasmic N-and the C-terminus. HCN1-4 mainly differ from each other with regard to their speed of activation and the extent by which they are modulated by cAMP. HCN1 is the fastest channel, followed by HCN2, HCN3 and HCN4.2, 3 The HCN3 channels are abundant in the brain where high expression of HCN3 mRNA was found in the hypothalamus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
HCN3 protein
NCBI Official Synonym Full Names
hyperpolarization activated cyclic nucleotide gated potassium channel 3
NCBI Official Symbol
HCN3
NCBI Protein Information
potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
NCBI Description
This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Research Articles on HCN3
Similar Products
Product Notes
The HCN3 (Catalog #AAA4159162) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-HCN3 Antibody reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HCN3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: Rat brain lysate (1:200). Researchers should empirically determine the suitability of the HCN3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HCN3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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