Western Blot (WB)
(Western Blotting rat brain membranes: 1. HCN2 1:200 2. HCN2 preincubated with control peptide antigen)
Rabbit anti-Rat HCN2 Polyclonal Antibody | anti-HCN2 antibody
HCN2 (Hyperpolarization-activated Cyclic Nucleotide-gated Cation Channel 2, BCNG2, HAC-1)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: Western Blot: 1:200-1:1000 with subsequent staining with HRP-goat anti-rabbit and detection by ECL, has been used with rat brain membranes.
Immunohistochemistry: Rat brain membrane sections
Western Blot (WB)
(Western Blotting rat brain membranes: 1. HCN2 1:200 2. HCN2 preincubated with control peptide antigen)
Western Blot (WB)
(Western Blotting rat brain membranes: 1. HCN2 1:200 2. HCN2 preincubated with control peptide antigen)
NCBI and Uniprot Product Information
NCBI Description
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM]
Uniprot Description
HCN2: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages. Belongs to the potassium channel HCN family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, cation
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane
Molecular Function: identical protein binding; voltage-gated potassium channel activity; intracellular cAMP activated cation channel activity; voltage-gated sodium channel activity; cAMP binding
Biological Process: synaptic transmission; regulation of membrane potential; cell-cell signaling
Research Articles on HCN2
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Product Notes
The HCN2 hcn2 (Catalog #AAA618305) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HCN2 (Hyperpolarization-activated Cyclic Nucleotide-gated Cation Channel 2, BCNG2, HAC-1) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HCN2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Suitable for use in Western Blot and Immunohistochemistry. Dilution: Western Blot: 1:200-1:1000 with subsequent staining with HRP-goat anti-rabbit and detection by ECL, has been used with rat brain membranes. Immunohistochemistry: Rat brain membrane sections. Researchers should empirically determine the suitability of the HCN2 hcn2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HCN2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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