Western Blot (WB)
(Western blot analysis of extracts of HL-60 cell lines, using HCK antibody.)
Rabbit HCK Polyclonal Antibody | anti-HCK antibody
HCK (Hemopoietic Cell Kinase, JTK9) (AP)
WB: 1:500-1:2000
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of extracts of HL-60 cell lines, using HCK antibody.)
Western Blot (WB)
(Western blot analysis of extracts of HL-60 cell lines, using HCK antibody.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]
Uniprot Description
Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization.
Protein type: Oncoprotein; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; EC 2.7.10.2; Kinase, protein; TK group; Src family
Chromosomal Location of Human Ortholog: 20q11-q12
Cellular Component: Golgi apparatus; extrinsic to internal side of plasma membrane; transport vesicle; focal adhesion; cell projection; lysosome; actin filament; caveola; nucleus; cytosol
Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: peptidyl-tyrosine phosphorylation; respiratory burst after phagocytosis; viral reproduction; protein amino acid autophosphorylation; regulation of phagocytosis; protein amino acid phosphorylation; regulation of cell shape; leukocyte migration during immune response; regulation of transcription factor activity; leukocyte degranulation; positive regulation of cell proliferation; lipopolysaccharide-mediated signaling pathway; mesoderm development; inflammatory response; innate immune response-activating signal transduction; cell adhesion; cell differentiation; integrin-mediated signaling pathway; cytokine and chemokine mediated signaling pathway; regulation of defense response to virus by virus; positive regulation of actin filament polymerization; regulation of inflammatory response; innate immune response; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
Research Articles on HCK
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Product Notes
The HCK hck (Catalog #AAA6419940) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HCK (Hemopoietic Cell Kinase, JTK9) (AP) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HCK can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), Western Blot (WB). IHC: 1:50-1:200 WB: 1:500-1:2000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the HCK hck for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HCK, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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