Rabbit hairy/enhancer-of-split related with YRPW motif 2 Polyclonal Antibody | anti-HEY2 antibody
Rabbit anti-human hairy/enhancer-of-split related with YRPW motif 2 polyclonal Antibody
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
HEY2: Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'- CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Belongs to the HEY family.
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: nucleoplasm; transcriptional repressor complex; Sin3 complex; cytoplasm; nucleus
Molecular Function: protein dimerization activity; protein binding; sequence-specific DNA binding; histone deacetylase binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; cardiac muscle hypertrophy; Notch signaling pathway; cell fate commitment; ventricular cardiac muscle cell development; positive regulation of heart rate; negative regulation of transcription from RNA polymerase II promoter; protein-DNA complex assembly; regulation of auditory receptor cell differentiation; negative regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; negative regulation of transcription, DNA-dependent; vasculogenesis; positive regulation of cardiac muscle cell proliferation; mesenchymal cell development; anterior/posterior axis specification
Research Articles on HEY2
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Product Notes
The HEY2 hey2 (Catalog #AAA711038) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human hairy/enhancer-of-split related with YRPW motif 2 polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's hairy/enhancer-of-split related with YRPW motif 2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). Researchers should empirically determine the suitability of the HEY2 hey2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "hairy/enhancer-of-split related with YRPW motif 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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