Rabbit anti-Human, Mouse HABP2 Polyclonal Antibody | anti-HABP2 antibody

HABP2, CT (HABP2, HGFAL, PHBP, Hyaluronan-binding protein 2, Factor VII-activating protease, Factor seven-activating protease, Hepatocyte growth factor activator-like protein, Plasma hyaluronan-binding protein, Hyaluronan-binding protein 2 50kD heavy chai

Cat. Num. AAA6305319

• Gene Names: HABP2; FSAP; HABP; PHBP; HGFAL; NMTC5
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, ELISA, Western Blot
• Purity: Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
• Synonyms: HABP2; Polyclonal Antibody; CT (HABP2; HGFAL; PHBP; Hyaluronan-binding protein 2; Factor VII-activating protease; Factor seven-activating protease; Hepatocyte growth factor activator-like protein; Plasma hyaluronan-binding protein; Hyaluronan-binding protein 2 50kD heavy chai; Hyaluronan-binding protein 2 50kD heavy chain; Hyaluronan-binding protein 2 50kD heavy chain alternate form; Hyaluronan-binding protein 2 27kD light chain; Hyaluronan-binding protein 2 27kD light chain alternate form; anti-HABP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-HABP2 antibody: Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
• Application Notes: IHC: 1:50-100; ELISA: 1:1,000; WB: 1:50-100; Applications are based on unconjugated antibody.
• Immunogen: HABP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 385-414 amino acids from the C-terminal region of human HABP2.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western blot analysis of HABP2 Antibody (C-term) in mouse liver tissue lysates (35ug/lane). HABP2 (arrow) was detected using the purified Pab.)

Immunohistochemistry (IHC)

(HABP2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of the HABP2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)

Related Product Information for anti-HABP2 antibody

HABP2 is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-HABP2 antibody

Antibodies; Growth Factors; Cytokines

References

Choi-Miura, N.H., et al. Biol. Pharm. Bull. 24(2):140-143(2001). Sumiya, J., et al. J. Biochem. 122(5):983-990(1997). Choi-Miura, N.H., et al. J. Biochem. 119(6):1157-1165(1996). Gupta, S., et al. Eur. J. Cell Biol. 56(1):58-67(1991).

NCBI and Uniprot Product Information

• NCBI GI #: 295054188
• NCBI GeneID: 3026
• NCBI Accession #: NP_004123
• NCBI GenBank Nucleotide #: NM_004132
• UniProt Accession #: Q14520
• Molecular Weight: 63kDa
• NCBI Official Full Name: hyaluronan-binding protein 2 isoform 2
• NCBI Official Synonym Full Names: hyaluronan binding protein 2
• NCBI Official Symbol: HABP2
• NCBI Official Synonym Symbols: FSAP; HABP; PHBP; HGFAL; NMTC5
• NCBI Protein Information: hyaluronan-binding protein 2
• UniProt Protein Name: Hyaluronan-binding protein 2
• Protein Family: Hyaluronan-binding protein
• UniProt Gene Name: HABP2
• UniProt Synonym Gene Names: HGFAL; PHBP; FSAP
• UniProt Entry Name: HABP2_HUMAN

NCBI Description

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by hepatocytes and proteolytically processed to generate heavy and light chains that form the mature heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This extracellular protease binds hyaluronic acid and may play a role in the coagulation and fibrinolysis systems. Mutations in this gene are associated with nonmedullary thyroid cancer and susceptibility to venous thromboembolism. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]