Western Blot (WB)
(GUCA1B Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GUCA1B antibody detected the GUCA1B protein (arrow).)
Rabbit anti-Human GUCA1B Polyclonal Antibody | anti-GUCA1B antibody
GUCA1B, NT (GUCA1B, GCAP2, Guanylyl cyclase-activating protein 2, Guanylate cyclase activator 1B) (APC)
FLISA: 1:1,000
Applications are based on unconjugated antibody.
Western Blot (WB)
(GUCA1B Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GUCA1B antibody detected the GUCA1B protein (arrow).)
Western Blot (WB)
(GUCA1B Antibody (N-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GUCA1B antibody detected the GUCA1B protein (arrow).)
NCBI and Uniprot Product Information
Uniprot Description
GCAP2: Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. Defects in GUCA1B are the cause of retinitis pigmentosa type 48 (RP48). RP48 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Protein type: Calcium-binding
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: photoreceptor inner segment
Molecular Function: calcium sensitive guanylate cyclase activator activity; calcium ion binding
Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of rhodopsin mediated signaling; visual perception; cell-cell signaling; receptor guanylyl cyclase signaling pathway; positive regulation of guanylate cyclase activity; body fluid secretion
Disease: Retinitis Pigmentosa 48
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Product Notes
The GUCA1B guca1b (Catalog #AAA6305065) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GUCA1B, NT (GUCA1B, GCAP2, Guanylyl cyclase-activating protein 2, Guanylate cyclase activator 1B) (APC) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GUCA1B can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), FLISA. WB: 1:100-500 FLISA: 1:1,000 Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the GUCA1B guca1b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GUCA1B, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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