Rabbit anti-Human GTF2IRD2B Polyclonal Antibody | anti-GTF2IRD2B antibody

GTF2IRD2B, CT (GTF2IRD2B, General transcription factor II-I repeat domain-containing protein 2B, Transcription factor GTF2IRD2-beta) (APC)

Cat. Num. AAA6304922

• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: GTF2IRD2B; Polyclonal Antibody; CT (GTF2IRD2B; General transcription factor II-I repeat domain-containing protein 2B; Transcription factor GTF2IRD2-beta) (APC); Transcription factor GTF2IRD2-beta; anti-GTF2IRD2B antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

• Applicable Applications for anti-GTF2IRD2B antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: GTF2IRD2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 467-494 amino acids from the C-terminal region of human GTF2IRD2B.
• Conjugate: APC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(GTF2IRD2B Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the GTF2IRD2B antibody detected the GTF2IRD2B protein (arrow).)

Related Product Information for anti-GTF2IRD2B antibody

This gene encodes a glycosylated phosphoprotein with a leucine zipper motif, two helix-loop-helix motifs (I repeats) that are similar to domains found in the TFII-I family of transcription factors, one CHARLIE8 transposable element-like sequence, and a BED zinc finger. This gene lies within a region that is deleted in Williams-Beuren syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Product Categories/Family for anti-GTF2IRD2B antibody

Antibodies; Transcription Factors

References

Hinsley, T.A., et al. Protein Sci. 13(10):2588-2599(2004). Tipney, H.J., et al. Eur. J. Hum. Genet. 12(7):551-560(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 51241788
• NCBI GeneID: 389524
• NCBI Accession #: NP_001003795.1
• NCBI GenBank Nucleotide #: NM_001003795.2
• UniProt Accession #: Q6EKJ0; Q69GU6; Q8N979; Q9H739; B2RNE9
• Molecular Weight: 24,920 Da
• NCBI Official Full Name: general transcription factor II-I repeat domain-containing protein 2B
• NCBI Official Synonym Full Names: GTF2I repeat domain containing 2B
• NCBI Official Symbol: GTF2IRD2B
• NCBI Protein Information: general transcription factor II-I repeat domain-containing protein 2B
• UniProt Protein Name: General transcription factor II-I repeat domain-containing protein 2B
• Protein Family: General transcription factor II-I repeat domain-containing protein
• UniProt Gene Name: GTF2IRD2B
• UniProt Synonym Gene Names: GTF2I repeat domain-containing protein 2B
• UniProt Entry Name: GTD2B_HUMAN

NCBI Description

This gene encodes a glycosylated phosphoprotein with a leucine zipper motif, two helix-loop-helix motifs (I repeats) that are similar to domains found in the TFII-I family of transcription factors, one CHARLIE8 transposable element-like sequence, and a BED zinc finger. This gene lies within a region that is deleted in Williams-Beuren syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Uniprot Description

GTF2IRD2B: GTF2IRD2B is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Belongs to the TFII-I family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: nucleus

Molecular Function: DNA binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent