Rabbit GSTO1 Polyclonal Antibody | anti-GSTO1 antibody

GSTO1 Polyclonal Antibody

Cat. Num. AAA3011426

• Gene Names: GSTO1; P28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: GSTO1; Polyclonal Antibody; GSTO1 Polyclonal Antibody; Glutathione S-transferase omega-1; GSTO-1; Glutathione S-transferase omega 1-1; GSTO 1-1; Glutathione-dependent dehydroascorbate reductase; Monomethylarsonic acid reductase; MMA(V) reductase; S-(Phenacyl)glutathione reductase; SPG-R; GSTTLP28; anti-GSTO1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GSTO1 polyclonal antibody detects endogenous levels of GSTO1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 213

• Applicable Applications for anti-GSTO1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:2000
• Immunogen: Recombinant full length Human GSTO1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of GSTO1 polyclonal antibody)

Related Product Information for anti-GSTO1 antibody

GSTO1 (glutathione S-transferase omega 1), also known as p28 or GSTTLp28, is a 241 amino acid protein that localizes to the cytoplasm and contains both an N-terminal and a C-terminal GST domain. Expressed ubiquitously with highest expression in heart, liver and skeletal muscle, GSTO1 exists as a homodimer that functions as both a glutathione-dependent thiol transferase and a dehydroascorbate reductase. Specifically, GSTO1 catalyzes the reaction of glutathione with a wide variety of organic compounds to form thioethers, a process that is essential for the metabolism and detoxification of a variety of xenobiotics and carcinogens. Human GSTO1 shares 70% sequence homology with its rodent counterpart, suggesting a conserved role between species. Polymorphisms in the gene encoding GSTO1 may be associated with the development of childhood acute lymphoblastic leukemia, Parkinson's disease and Alzheimer disease.

NCBI and Uniprot Product Information

• NCBI GI #: 300360534
• NCBI GeneID: 9446
• NCBI Accession #: NP_001177932.1
• NCBI GenBank Nucleotide #: NP_001177932.1
• UniProt Accession #: P78417
• Molecular Weight: ~ 28kDa
• NCBI Official Full Name: glutathione S-transferase omega-1 isoform 3
• NCBI Official Synonym Full Names: glutathione S-transferase omega 1
• NCBI Official Symbol: GSTO1
• NCBI Official Synonym Symbols: P28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21
• NCBI Protein Information: glutathione S-transferase omega-1
• UniProt Protein Name: Glutathione S-transferase omega-1
• Protein Family: Glutathione S-transferase
• UniProt Gene Name: GSTO1
• UniProt Synonym Gene Names: GSTTLP28; GSTO-1; GSTO 1-1; MMA(V) reductase; SPG-R
• UniProt Entry Name: GSTO1_HUMAN

NCBI Description

The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Uniprot Description

GSTO1: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family.

Protein type: EC 1.8.5.1; EC 2.5.1.18; Transferase; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.20.4.2; Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: 10q25.1

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; glutathione transferase activity; glutathione dehydrogenase (ascorbate) activity; methylarsonate reductase activity; oxidoreductase activity

Biological Process: positive regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion; xenobiotic metabolic process; L-ascorbic acid metabolic process; xenobiotic catabolic process