GSTO1 recombinant protein

GSTO1; Human Recombinant

Cat. Num. AAA8400674

• Gene Names: GSTO1; P28; SPG-R; GSTO 1-1; GSTTLp28
• Purity: >95% by SDS-PAGE
• Synonyms: GSTO1; Human Recombinant; Glutathione S-transferase omega-1; GSTO 1-1;mMA(V) reductase; GSTO1 recombinant protein

• Host: E Coli
• Specificity: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl buffer (pH8.0) containing 1mM DTT 10% glycerol
• Sequence Positions: aa1-241

• Source: Human
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shipping: Gel Pack; Shelf Life: Est.~12 months; Country of Origin: USA

SDS-Page

Related Product Information for GSTO1 recombinant protein

GSTO1, also known as p28 or GSTTLp28, is a protein that localizes to the cytoplasm and contains both an Nterminal and a C-terminal GST domain. In mouse, the encoded protein acts as a small stress response protein, likely involved in cellular redox homeostasis. This protein has dehydroascorbate reductase activity and may function in the glutathione-ascorbate cycle as part of antioxidant metabolism. Recombinant human GSTO1 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for GSTO1 recombinant protein

Web Categories; Proteins and Enzymes; Proteins and Enzymes (A-Z); Signal Transduction; Enzymes & Proteases; Other Proteins & Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 300360534
• NCBI GeneID: 9446
• NCBI Accession #: NP_001177932.1
• NCBI GenBank Nucleotide #: NM_001191003.1
• UniProt Accession #: P78417; Q5TA03; Q7Z3T2; D3DRA3; F5H7H0
• Molecular Weight: 27,566 Da
• NCBI Official Full Name: glutathione S-transferase omega-1 isoform 3
• NCBI Official Synonym Full Names: glutathione S-transferase omega 1
• NCBI Official Symbol: GSTO1
• NCBI Official Synonym Symbols: P28; SPG-R; GSTO 1-1; GSTTLp28
• NCBI Protein Information: glutathione S-transferase omega-1; GSTO-1; MMA(V) reductase; glutathione-S-transferase like; monomethylarsonic acid reductase; S-(Phenacyl)glutathione reductase; glutathione S-transferase omega 1-1; glutathione-dependent dehydroascorbate reductase
• UniProt Protein Name: Glutathione S-transferase omega-1
• Protein Family: Glutathione S-transferase
• UniProt Gene Name: GSTO1
• UniProt Synonym Gene Names: GSTTLP28; GSTO-1; GSTO 1-1; MMA(V) reductase; SPG-R
• UniProt Entry Name: GSTO1_HUMAN

NCBI Description

The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Uniprot Description

GSTO1: Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid. Belongs to the GST superfamily. Omega family.

Protein type: EC 1.8.5.1; EC 2.5.1.18; Transferase; Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.20.4.2; Other Amino Acids Metabolism - glutathione; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: 10q25.1

Cellular Component: cytoplasm; cytosol

Molecular Function: protein binding; glutathione transferase activity; glutathione dehydrogenase (ascorbate) activity; methylarsonate reductase activity; oxidoreductase activity

Biological Process: positive regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion; xenobiotic metabolic process; L-ascorbic acid metabolic process; xenobiotic catabolic process