Western Blot (WB)
(WB Suggested Anti-GSK3A Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysateGSK3A is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells)
Rabbit GSK3A Polyclonal Antibody | anti-GSK3A antibody
GSK3A antibody - N-terminal region
Western Blot (WB)
(WB Suggested Anti-GSK3A Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysateGSK3A is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells)
Western Blot (WB)
(WB Suggested Anti-GSK3A Antibody Titration: 1.25ug/mlPositive Control: HepG2 cell lysateGSK3A is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells)
Target Description: GSK3alpha is a potential regulator of platelet function and improves insulin action and glucose metabolism in skeletal muscle.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011]
Uniprot Description
GSK3A: a proline-directed protein kinase of the GSK family. Implicated in the control of several regulatory proteins including glycogen synthase, Myb, and c-Jun. GSK3 and GSK3 have similar functions. GSK3 phophorylates tau, the principal component of neurofibrillary tangles in Alzheimer disease and is required for maximal production of amyloid plaque peptides by secretase. A GSK3 promoter SNP effects progression of bipolar disorder. The GSK3 inhibitor, lithium, is used to treat bipolar disorder and is seen to block plaque formation. GSK3 generally opposes the action of insulin, and GSK3 hyperactivity is thought to contribute to insulin resistant (type II) diabetes. GSK3 also negatively regulates cardiac hypertrophy. A tumor suppressor role is indicated by the oncogenic potential of stabilized -catenin mutants that lack GSK3 phosphorylation sites. Inhibitor: AR-A014418
Protein type: EC 2.7.11.1; EC 2.7.11.26; Protein kinase, CMGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); CMGC group; GSK family; GSK subfamily
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: beta-catenin destruction complex; cytosol
Molecular Function: protein serine/threonine kinase activity; protein binding; tau-protein kinase activity; ATP binding
Biological Process: glycogen metabolic process; proteasomal ubiquitin-dependent protein catabolic process; genetic imprinting; nerve growth factor receptor signaling pathway; negative regulation of insulin receptor signaling pathway; protein amino acid phosphorylation; negative regulation of transferase activity; positive regulation of cAMP biosynthetic process; negative regulation of glycogen biosynthetic process; epidermal growth factor receptor signaling pathway; nervous system development; negative regulation of TOR signaling pathway; cell migration; phosphoinositide-mediated signaling; Wnt receptor signaling pathway; fibroblast growth factor receptor signaling pathway; unfolded protein response; positive regulation of peptidyl-serine phosphorylation; negative regulation of glucose import; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; cellular response to insulin stimulus; regulation of systemic arterial blood pressure; insulin receptor signaling pathway; positive regulation of protein catabolic process; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of heart contraction
Research Articles on GSK3A
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Product Notes
The GSK3A gsk3a (Catalog #AAA3224335) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GSK3A antibody - N-terminal region reacts with Cow, Dog, Human, Mouse, Pig, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GSK3A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the GSK3A gsk3a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: MSGGGPSGGG PGGSGRARTS SFAEPGGGGG GGGGGPGGSA SGPGGTGGGK. It is sometimes possible for the material contained within the vial of "GSK3A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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