Western Blot (WB)
(Western blot analysis GSG2 using Jurkat whole cell lysates)
Rabbit anti-Human GSG2 Polyclonal Antibody | anti-GSG2 antibody
GSG2 Antibody
Gene Names
HASPIN; GSG2
Reactivity
Human
Applications
Western Blot, ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Synonyms
GSG2; Polyclonal Antibody; GSG2 Antibody; germ cell associated 2; Germ cell-specific gene 2 protein; H-haspin; Haploid germ cell-specific nuclear protein kinase; HASP_HUMAN; Serine/threonine-protein kinase haspin; anti-GSG2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
GSG2 antibody detects endogenous levels of total GSG2
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Sequence Length
798
Applicable Applications for anti-GSG2 antibody
Western Blot (WB), ELISA (EIA)
Application Notes
WB: 1:1000-3000
Immunogen
A synthesized peptide derived from human GSG2
Subcellular Location
Nucleus.
Tissue Specificity
Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Western Blot (WB)
(Western blot analysis GSG2 using Jurkat whole cell lysates)
Western Blot (WB)
(Western blot analysis GSG2 using Jurkat whole cell lysates)
Related Product Information for anti-GSG2 antibody
Function: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
Post-translational Modifications: Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis.
Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
Post-translational Modifications: Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis.
Similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Observed: 88 kDa
Predicted: 89 kDa
Predicted: 89 kDa
NCBI Official Full Name
serine/threonine-protein kinase haspin
NCBI Official Synonym Full Names
histone H3 associated protein kinase
NCBI Official Symbol
HASPIN
NCBI Official Synonym Symbols
GSG2
NCBI Protein Information
serine/threonine-protein kinase haspin
UniProt Protein Name
Serine/threonine-protein kinase haspin
Protein Family
UniProt Gene Name
HASPIN
Uniprot Description
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.
Research Articles on GSG2
Similar Products
Product Notes
The GSG2 haspin (Catalog #AAA9609166) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GSG2 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GSG2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB: 1:1000-3000. Researchers should empirically determine the suitability of the GSG2 haspin for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GSG2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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