Rabbit anti-Human Growth Hormone Releasing Factor Polyclonal Antibody | anti-GHRH antibody

Growth Hormone Releasing Factor (GHRF, GHRH)

Cat. Num. AAA619234

• Gene Names: GHRH; GRF; INN; GHRF; MGC119781
• Reactivity: Human
• Applications: ELISA
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: Growth Hormone Releasing Factor; Polyclonal Antibody; Growth Hormone Releasing Factor (GHRF; GHRH); Anti -Growth Hormone Releasing Factor (GHRF; anti-GHRH antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human growth hormone releasing factor
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in 0.1M Tris-HCl, pH 7.5.

• Applicable Applications for anti-GHRH antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.
• Immunogen: Growth hormone releasing factor
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-GHRH antibody

Glucagon is a member of a multigene family comprising of Secretin, Vasoactive Intestinal Peptide (VIP), Gastric Inhibitory Peptide (GIP) and others like Glicentin and Oxyntomodulin (OXM), which differs from glucagon by C-terminal octapeptide.  The glucagon precursor contains at least 3 intervening sequences that divide the protein-coding portion into 4 regions corresponding to the signal peptide and part of the N-terminal peptide, the remainder of the N-terminal peptide and glucagon, glucagon-like peptide-1 (GLP1), and GLP2. The GLP 1 & 2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crupt cell proliferation and decreased enterocyte apoptosis. The two GLP's are mainly produced in the A cells of the Islets of Langerhans in response to a drop in blood sugar concentration.

GRF (Growth hormone-releasing factor) 44 aa peptide (chr 20q11.2) with a mass of 13kD is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of Growth Hormone, GRF is mainly secreted by pancreatic islet cells, its antagonists inhibit the growth of various cancers in vivo. This effect is exerted in part by endocrinemechanisms through the inhibition of growth hormone (GH) releasefrom the pituitary.

Product Categories/Family for anti-GHRH antibody

Antibodies; Abs to Hormones; Steroids

NCBI and Uniprot Product Information

• NCBI GI #: 337133
• NCBI GeneID: 2691
• UniProt Accession #: P01286; Q4KN10; Q5JYR1
• Molecular Weight: 12,447 Da
• NCBI Official Full Name: growth hormone releasing factor
• NCBI Official Synonym Full Names: growth hormone releasing hormone
• NCBI Official Symbol: GHRH
• NCBI Official Synonym Symbols: GRF; INN; GHRF; MGC119781
• NCBI Protein Information: somatoliberin; sermorelin; somatorelin; somatocrinin; OTTHUMP00000030915; OTTHUMP00000030916; growth hormone-releasing factor; growth hormone-releasing hormone
• UniProt Protein Name: Somatoliberin
• Protein Family: Somatoliberin
• UniProt Gene Name: GHRH
• UniProt Synonym Gene Names: GHRF
• UniProt Entry Name: SLIB_HUMAN

NCBI Description

The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. [provided by RefSeq]

Uniprot Description

GHRH: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. Belongs to the glucagon family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q11.2

Cellular Component: extracellular space; extracellular region; terminal button

Molecular Function: growth hormone-releasing hormone activity; growth hormone-releasing hormone receptor binding

Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; response to food; positive regulation of growth hormone secretion; growth hormone secretion; cAMP-mediated signaling; positive regulation of circadian sleep/wake cycle, REM sleep; cell-cell signaling; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; adenohypophysis development; positive regulation of multicellular organism growth; G-protein signaling, adenylate cyclase activating pathway