Rabbit Growth hormone receptor Polyclonal Antibody | anti-GHR antibody

Growth hormone receptor Rabbit pAb

Cat. Num. AAA4754689

• Gene Names: GHR; GHBP
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity purified
• Synonyms: Growth hormone receptor; Polyclonal Antibody; Growth hormone receptor Rabbit pAb; growth hormone receptor; GHBP; GHIP; anti-GHR antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver. Gene expression databases
• Purity/Purification: Affinity purified
• Form/Format: pH7.4 PBS, 0.05% NaN3, 40% Glycerol

• Applicable Applications for anti-GHR antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:2000; ELISA: 1:2000-1:5000
• Immunogen: Synthetic peptide of human GHR
• Conjugation: Unconjugated
• Molecular Function: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway.
• Modification: Unmodified
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-4: Raji, K562, skov3 and pc3 cell, Primary antibody: 160428(GHR Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds)

Related Product Information for anti-GHR antibody

This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature.

Product Categories/Family for anti-GHR antibody

Primary antibody

NCBI and Uniprot Product Information

• NCBI GI #: 4503993
• NCBI GeneID: 2690
• NCBI Accession #: NP_000154.1
• NCBI GenBank Nucleotide #: NM_000163.4
• UniProt Accession #: P10912; Q9HCX2
• Molecular Weight: 71,500 Da
• NCBI Official Full Name: growth hormone receptor isoform 1
• NCBI Official Synonym Full Names: growth hormone receptor
• NCBI Official Symbol: GHR
• NCBI Official Synonym Symbols: GHBP
• NCBI Protein Information: growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein
• UniProt Protein Name: Growth hormone receptor
• Protein Family: Growth hormone receptor
• UniProt Gene Name: GHR
• UniProt Synonym Gene Names: GH receptor; GH-binding protein; GHBP
• UniProt Entry Name: GHR_HUMAN

NCBI Description

This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

Uniprot Description

GH receptor: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. Defects in GHR are a cause of Laron syndrome (LARS). A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the type I cytokine receptor family. Type 1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5p13-p12

Cellular Component: extracellular space; cell surface; integral to plasma membrane; extracellular region; plasma membrane; integral to membrane; receptor complex

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein homodimerization activity; peptide hormone binding; growth factor binding; protein kinase binding

Biological Process: succinate metabolic process; oxaloacetate metabolic process; activation of MAPK activity; positive regulation of multicellular organism growth; tyrosine phosphorylation of JAK2 protein; fatty acid metabolic process; response to estradiol stimulus; 2-oxoglutarate metabolic process; positive regulation of tyrosine phosphorylation of Stat3 protein; allantoin metabolic process; receptor internalization; creatinine metabolic process; isoleucine metabolic process; cytokine and chemokine mediated signaling pathway; valine metabolic process; citrate metabolic process; regulation of multicellular organism growth; endocytosis; JAK-STAT cascade; creatine metabolic process; multicellular organismal metabolic process; cellular response to hormone stimulus; positive regulation of peptidyl-tyrosine phosphorylation; insulin-like growth factor receptor signaling pathway; positive regulation of tyrosine phosphorylation of Stat5 protein; response to cycloheximide; taurine metabolic process

Disease: Hypercholesterolemia, Familial; Laron Syndrome