Western Blot (WB)
(Western Blot: Sample: Lane1: Rat Brain Tissue; Lane2: Porcine Brain Tissue.)
Rabbit anti-Human Growth Associated Protein 43 Polyclonal Antibody | anti-GAP43 antibody
Polyclonal Antibody to Growth Associated Protein 43 (GAP43)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- MTKSCSELCH PALHFLPCLG GLRKNLQRAV RPSPYSLGFL TFWISRVEKN DDDQKIEQDG IKPEDKAHKA ATKIQASFRG HITRKKLKGE KKDDVQAAEA EANKKDEAPV ADGVEKKGEG TTTAEAAPAT GSKPDEPGKA GETPSEEKKG EGDAATEQAA PQAPASSEEK AGSAETESAT KASTDNSPSS KAEDAPAKEE PKQADVPAAV TAAAATTPAA EDAAAKATAQ PPTETGESSQ AEENIEAVDE TKPKESARQD
Immunocytochemistry in formalin fixed cells: 5-20ug/mL
Immunohistochemistry in formalin fixed frozen section: 5-20ug/mL
Immunohistochemistry in paraffin section: 5-20ug/mL
Enzyme-linked Immunosorbent Assay: 0.05-2ug/mL
Optimal working dilutions must be determined by end user.
Western Blot (WB)
(Western Blot: Sample: Lane1: Rat Brain Tissue; Lane2: Porcine Brain Tissue.)
Western Blot (WB)
(Western Blot: Sample: Lane1: Rat Brain Tissue; Lane2: Porcine Brain Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant GAP43, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant GAP43, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Brain Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Brain Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Pancreas Cancer Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Pancreas Cancer Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Breast Cancer Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Breast Cancer Tissue)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
GAP43: This protein is associated with nerve growth. It is a major component of the motile growth cones that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence. Belongs to the neuromodulin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell surface
Chromosomal Location of Human Ortholog: 3q13.31
Cellular Component: axon; cell junction; cytoplasm; filopodium membrane; plasma membrane; postsynaptic density
Molecular Function: calmodulin binding; phosphatidylinositol phosphate binding; phosphatidylserine binding; protein binding
Biological Process: axon choice point recognition; axon guidance; cell fate commitment; glial cell differentiation; protein kinase C-activating G-protein coupled receptor signaling pathway; regulation of filopodium formation; regulation of growth; response to wounding; tissue regeneration
Research Articles on GAP43
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Product Notes
The GAP43 gap43 (Catalog #AAA2028621) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Growth Associated Protein 43 (GAP43) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Growth Associated Protein 43 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA). Western blotting: 1-5ug/mL Immunocytochemistry in formalin fixed cells: 5-20ug/mL Immunohistochemistry in formalin fixed frozen section: 5-20ug/mL Immunohistochemistry in paraffin section: 5-20ug/mL Enzyme-linked Immunosorbent Assay: 0.05-2ug/mL Optimal working dilutions must be determined by end user. Researchers should empirically determine the suitability of the GAP43 gap43 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- MTKSCSELCH PALHFLPCLG GLRKNLQRAV RPSPYSLGFL TFWISRVEKN DDDQKIEQDG IKPEDKAHKA ATKIQASFRG HITRKKLKGE KKDDVQAAEA EANKKDEAPV ADGVEKKGEG TTTAEAAPAT GSKPDEPGKA GETPSEEKKG EGDAATEQAA PQAPASSEEK AGSAETESAT KASTDNSPSS KAEDAPAKEE PKQADVPAAV TAAAATTPAA EDAAAKATAQ PPTETGESSQ AEENIEAVDE TKPKESARQD. It is sometimes possible for the material contained within the vial of "Growth Associated Protein 43, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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