Rabbit anti-Rat GRO/KC Polyclonal Antibody | anti-Cxcl1 antibody

GRO/KC

Cat. Num. AAA611087

• Gene Names: Cxcl1; Gro1; CINC-1
• Reactivity: Rat
• Applications: ELISA, Western Blot, Neutralization Assay
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: GRO/KC; Polyclonal Antibody; Anti -GRO/KC; anti-Cxcl1 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes rat GRO/KC.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH7.2, 40% glycerol.

• Applicable Applications for anti-Cxcl1 antibody: ELISA (EL/EIA), Western Blot (WB), Neutralization
• Application Notes: Suitable for use in ELISA, Western Blot and Neutralization.; Dilution: ELISA: 0.5ug/ml (100ul/well).; Western Blot: 0.1-0.2ug/ml. Use 1.5-3.0ng/lane as the detection limit for recombinant rat GRO/KC.; Neutralization: 5-10ug/ml.
• Immunogen: Highly purified (>98%) recombinant antigen.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-Cxcl1 antibody

All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8kD protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

Product Categories/Family for anti-Cxcl1 antibody

Antibodies; Abs to Growth Factors; Cytokines

NCBI and Uniprot Product Information

• NCBI GI #: 13540652
• NCBI GeneID: 81503
• NCBI Accession #: NP_110472.1
• NCBI GenBank Nucleotide #: NM_030845.1
• UniProt Accession #: P14095
• Molecular Weight: 10,249 Da
• NCBI Official Full Name: growth-regulated alpha protein
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) ligand 1
• NCBI Official Symbol: Cxcl1
• NCBI Official Synonym Symbols: Gro1; CINC-1
• NCBI Protein Information: growth-regulated alpha protein; C-X-C motif chemokine 1; cytokine-induced neutrophil chemoattractant 1; platelet-derived growth factor-inducible protein KC; chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
• UniProt Protein Name: Growth-regulated alpha protein
• Protein Family: Growth-regulated alpha protein
• UniProt Gene Name: Cxcl1
• UniProt Synonym Gene Names: Cinc1; Gro; Scyb1; CINC-1
• UniProt Entry Name: GROA_RAT

NCBI Description

acts as a neutrophil chemoattractant; may play a role in acute phase inflammatory response [RGD, Feb 2006]

Uniprot Description

CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Cellular Component: extracellular space

Molecular Function: growth factor activity; chemokine activity; CXCR chemokine receptor binding

Biological Process: neutrophil chemotaxis; response to amphetamine; response to glucocorticoid stimulus; positive regulation of potassium ion transport; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; response to estradiol stimulus; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; response to heat; positive regulation of superoxide release; response to molecule of bacterial origin; response to gamma radiation; immune response; acute inflammatory response