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Rabbit anti-Rat GRO GRO beta Polyclonal Antibody | anti-GRO beta antibody

GRO beta antibody

Gene Names
CXCL2; GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a
Reactivity
Rat GRO
Applications
ELISA, Western Blot
Synonyms
GRO beta; Polyclonal Antibody; GRO beta antibody; Polyclonal GRO beta; Anti-GRO beta; Growth Regulated/Melanoma Growth Stimulatory Activity; MGSAbeta; GRO2; MIP-2; CXCL2; anti-GRO beta antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Rat GRO
Clonality
Polyclonal
Specificity
Rat GRO
Form/Format
Lyophilized from PBS, pH 7.2.
Sequence Length
3
Applicable Applications for anti-GRO beta antibody
ELISA (EIA), Inhibition, Western Blot (WB)
Application Notes
ELISA: 0.5-2 ug/ml
Inhibition: 3-5 ug/ml
WB: 0.1-0.2 ug/ml
Biological Significance
All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO-beta/MIP-2 is a 7.9 kDa protein consisting of 73 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.
Immunogen
GRO beta antibody was raised in rabbit using highly pure recombinant rat GRObeta/MIP-2 as the immunogen.
Preparation and Storage
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-GRO beta antibody
Affinity purified Rabbit polyclonal GRO beta antibody
Product Categories/Family for anti-GRO beta antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
7.9 kDa (predicted detection band MW)
NCBI Official Full Name
GRO-beta, partial
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 2
NCBI Official Symbol
CXCL2
NCBI Official Synonym Symbols
GRO2; GROb; MIP2; MIP2A; SCYB2; MGSA-b; MIP-2a; CINC-2a
NCBI Protein Information
C-X-C motif chemokine 2
UniProt Protein Name
C-X-C motif chemokine 2
UniProt Gene Name
CXCL2
UniProt Synonym Gene Names
GRO2; GROB; MIP2A; SCYB2; Gro-beta; MIP2-alpha; HSF
UniProt Entry Name
CXCL2_HUMAN

NCBI Description

This antimicrobial gene is part of a chemokine superfamily that encodes secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CXC subfamily, is expressed at sites of inflammation and may suppress hematopoietic progenitor cell proliferation. [provided by RefSeq, Sep 2014]

Uniprot Description

CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity; CXCR chemokine receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; response to molecule of bacterial origin; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; immune response; chemotaxis; inflammatory response; regulation of cell proliferation

Research Articles on GRO beta

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Product Notes

The GRO beta cxcl2 (Catalog #AAA535757) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GRO beta antibody reacts with Rat GRO and may cross-react with other species as described in the data sheet. AAA Biotech's GRO beta can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Inhibition, Western Blot (WB). ELISA: 0.5-2 ug/ml Inhibition: 3-5 ug/ml WB: 0.1-0.2 ug/ml. Researchers should empirically determine the suitability of the GRO beta cxcl2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GRO beta, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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